i(X)(p10) in male patients
2016-12-01 Tatiana Gindina Affiliation1.R.M. Gorbacheva Research Institute of Pediatric Oncology Hematology and Transplantation at First Saint-Petersburg State Medical University named I.P.Pavlov, Saint-Petersburg, Russia / [email protected]
Abstract
Review on i(X)(p10) in male patients
Clinics and Pathology
Disease
Extremely rarely i(X)(p10) occurs in male patients; only three cases has been reported in lymphoid malignancies, including ALL (Martineau et al, 1996; Gerr et al., 2010) and Follicular lymphoma (Donti et al., 1988).
Phenotype stem cell origin
Trilineage immunophenotype of lymphoblasts in one patient (Gerr et al, 2010); CD19+,CD10- in another one (Martineau et al, 1996).
Epidemiology
Table 1. Reported cases with i(X)(p10).
| # | Age, gender | Disease | Karyotype | Author |
| 1 | 33, M | ALL | 46,X,+i(X)(p10),-Y/46,idem,del(17)(p12p13)/46,idem,del(7)(q32q36),del(17) | Martineau et al, 1996 |
| 2 | 9, M | ALL | 50,Y,i(X)(p10),add(2)(p25),-13,+mar1~5 | Gerr et al, 2010 |
| 3 | 57, M | FL | 49,XY,+i(X)(q10),+i(X)(p10),add(1)(q?),+12,add(14)(q?)(6)/48,Y,i(X)(q10),+i(X)(p10), add(1),t(2;8)(p12;q24),+12,add(14)(2)/46,XX(2) | Donti et al, 1988 |
Prognosis
Survival was 12 months in one case (Gerr et al, 2010).
Genes Involved and Proteins
Result of the Chromosomal Anomaly
Oncogenesis
The major consequence of this abnormality is loss of several genes on Xq and gain of several genes on Xp, that leads to genetic imbalance.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
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Citation
Tatiana Gindina
i(X)(p10) in male patients
Atlas Genet Cytogenet Oncol Haematol. 2016-12-01
Online version: http://atlasgeneticsoncology.org/haematological/1496/i(x)(p10)-in-male-patients
