1.Kuwait Cancer Control Center, Department of Hematology, Laboratory of Cancer Genetics, Kuwait; email@example.com
Deletions of the short arm of chromosome 1 are observed in a broad range of hematological malignances including myeloid disorders, acute lymphoblastic leukemia (ALL), multiple myeloma (MM) and lymphomas. They generally occur as part of complex karyotypes and in advanced disease stages. Their association with complex karyotypes likely reflect an inherent chromosomal instability correlated with a poor prognosis. The occurrence of 1p deletions as a sole anomaly is infrequent and their clinical significance is less well characterized.
Atlas Genet Cytogenet Oncol Haematol. 2017-05-01
Online version: http://atlasgeneticsoncology.org/haematological/1501/del(1p)-solely