t(8;11)(p12;p15) ?/FGFR1

2008-07-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

Acute meyloid leukaemia (AML)

Epidemiology

Two cases to date, two male patients, one was aged 50 yrs, and had a M4-AML (Larson et al 1983; Sohal et al, 2001).

Prognosis

One patient died "following chemotherapy", the other one at 19 mths after diagnosis.

Genes Involved and Proteins

Note
In one case (Sohal et al, 2001), the genes were studied. FGFR1 was found involved; the breakpoint on the other chromosome fell within or near NUP98, but the involvement of NUP98 could not be proved.
Gene name
FGFR1 (Fibroblast Growth Factor Receptor 1)
Location
8p11.23
Protein description
Receptor tyrosine kinase; contains an extracellular ligand-binding domain with Ig-like structures, a transmembrane domain, and a cytosolic tyrosine kinase (TK) domain. Involved in signal transduction

Bibliography

Pubmed IDLast YearTitleAuthors
66272221983The predictive value of initial cytogenetic studies in 148 adults with acute nonlymphocytic leukemia: a 12-year study (1970-1982).Larson RA et al
115502832001Identification of four new translocations involving FGFR1 in myeloid disorders.Sohal J et al

Citation

Jean-Loup Huret

t(8;11)(p12;p15) ?/FGFR1

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/haematological/1521/t(8;11)(p12;p15)

External Links