t(1;6)(p36;p21)

2008-12-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

Myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML), but also chronic lymphoproliferative diseases (CLD)

Phenotype stem cell origin

The MDS case was a refractory anaemia with ringed sideroblasts (RARS), the AML case was a treatment related leukaemia (t-AML) (Hirst et al., 1993; Olney et al., 2002). The two CLD cases were chronic lymphocytic leukaemia (CLL) cases, one of which being atypical (Datta et al., 1991; Martin-Subero et al., 2007). This translocation is likely to be heterogenous.

Epidemiology

Only four cases to date; the case with RARS was a 72-year-old male patient, the t-AML case was also a male patient; the CLL cases (1 male and 1 female patients) were aged 35 and 75.

Prognosis

No data.

Genes Involved and Proteins

Note
Genes involved are unknown.

Bibliography

Pubmed IDLast YearTitleAuthors

Citation

Jean-Loup Huret

t(1;6)(p36;p21)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/haematological/1530/js/web-card-haematological.js