t(1;12)(q21;q24)

2009-09-01   Sang-Guk Lee , Sang-Guk Lee , Sang-Guk Lee 

1.Department of Laboratory Medicine, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul 120-752, Korea (SGL); Department of Laboratory Medicine, Kyung Hee University College of Medicine, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-702, Korea (TSP); Department of Laboratory Medicine, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul 120-752, Korea (JRC)
2.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

Acute myeloid leukaemia (AML), myelodysplastic syndrome (MDS)

Epidemiology

Only 3 cases to date, a 24-year-old female patient with a M2-AML, a patient with a treatment related AML (t-AML), and a 48-year-old patient with MDS ((Koo et al., 1998; Olney et al., 2002; Park et al., 2009). Although it is a rare chromosomal abnormality, it may be an aberration related to myeloid neoplasms including AML and MDS.

Prognosis

No detailed data available. However, one of them (Park et al., 2009) received bone marrow transplantation; complete donor chimerism was maintained for thirteen months until last follow up.

Cytogenetics

Cytogenetics morphological

It shows balanced chromosomal translocation between 1q21 and 12q24.

Additional anomalies

The patient with a M2-AML also had an i(17q). The patient with a MDS had +8, +der(12)t(1;12) additionally.

Genes Involved and Proteins

Note
The genes involved in this anomaly are unknown.

Bibliography

Pubmed IDLast YearTitleAuthors
94604921998Cytogenetic and fluorescence in situ hybridization analyses of hematologic malignancies in Korea.Koo SH et al
119212752002Unique balanced chromosome abnormalities in treatment-related myelodysplastic syndromes and acute myeloid leukemia: report from an international workshop.Olney HJ et al
196970272010A novel t(1;12)(q21;q24) in a patient with myelodysplastic syndrome.Park TS et al

Summary

Atlas Image

Citation

Sang-Guk Lee ; Sang-Guk Lee ; Sang-Guk Lee

t(1;12)(q21;q24)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/haematological/1531/t(1;12)(q21;q24)

Historical Card

2008-12-01 t(1;12)(q21;q24) by  Jean-Loup Huret 

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

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