t(2;19)(p23;p13) TPM4/ALK

2013-01-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Clinics

Only one case to date, an 18-month-old boy with a null-ALCL (Meech et al., 2001).

Cytology

Cells expressed both myeloid (CD13, CD33, HLA-DR) and natural killer (CD3-/CD56+, germline TCR genes, CD25+/CD122+/granzyme B+) cell antigens.

Evolution

The patient was in remission 14 months after completion of therapy.

Genes Involved and Proteins

Gene name
ALK (anaplastic lymphoma receptor tyrosine kinase)
Location
2p23.2
Protein description
1620 amino acids; ALK is a membrane associated tyrosine kinase receptor of the insulin receptor superfamily.
Gene name
TPM4 (tropomyosin)
Location
19p13.12
Protein description
248 amino acids; tropomyosins are actin-binding proteins; component of cytoskeletal microfilaments; role in the calcium dependent regulation of striated muscle.

Result of the Chromosomal Anomaly

Description

5TPM4-3ALK. Fusion between TPM4 nucleotide 714 and ALK nucleotide 4084.

Bibliography

Pubmed IDLast YearTitleAuthors
109341422000TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors.Lawrence B et al
114934722001Unusual childhood extramedullary hematologic malignancy with natural killer cell properties that contains tropomyosin 4--anaplastic lymphoma kinase gene fusion.Meech SJ et al
162133622005Detection of ETV6 and RUNX1 gene rearrangements using fluorescence in situ hybridization in Mexican patients with acute lymphoblastic leukemia: experience at a single institution.Pérez-Vera P et al

Summary

Fusion gene

TPM4/ALK TPM4 (19p13.12) ALK (2p23.2) COF 441 442|TPM4/ALK TPM4 (19p13.12) ALK (2p23.2) M t(2;19)(p23;p13)|TPM4/ALK TPM4 (19p13.12) ALK (2p23.2) TIC

Citation

Jean-Loup Huret

t(2;19)(p23;p13) TPM4/ALK

Atlas Genet Cytogenet Oncol Haematol. 2013-01-01

Online version: http://atlasgeneticsoncology.org/haematological/1549/t(2;19)(p23;p13)

External Links