t(14;17)(q32;q21) IGH/IGF2BP1
2014-10-01 Sarah South , Guangyu Gu Affiliation1.Genetics Associates, Inc. Nashville, TN [email protected] (GG); Department of Pathology, University of Utah; ARUP Institute for Clinical, Experimental Pathology, ARUP Laboratories, Salt Lake City, UT [email protected] (SS)
Abstract
IGH rearrangements are a common chromosomal abnormality seen in lymphoproliferative disorders, including ALL. Numerous translocation partners of IGH gene have been identified. Here we report a B-ALL case with a t(14;17)(q32;q21) IGH/IGF2BP1.
Clinics and Pathology
Disease
B-cell acute lymphoblastic leukemia (ALL)
Phenotype stem cell origin
CD10+, CD19+, CD38+, cytoplastic CD22+ ALL
Epidemiology
Only one case, a 16 year old boy (Gu et al., 2014)
Clinics
Severe pancytopenia and an elevated lactate dehydrogenase (1048U/L); WBC was 2.7 X 10 9 with 20% blasts; no central nervous system involvement.
Genes Involved and Proteins
Gene name
IGH (Immunoglobulin Heavy)
Location
14q32.33
Gene name
IGF2BP1 (insulin-like growth factor 2 mRNA binding protein 1)
Location
17q21.32
Protein description
IGF2BP1 is a member of Insulin-like growth factor 2 mRNA-binding protein family; pro-oncogenic RNA-binding; post-transcriptional regulation of gene expression (Bell et al., 2013; Lederer et al., 2014).
Result of the Chromosomal Anomaly
Description
likely head-to-head fusion of IGF2BP1 with the IGH locus.
Oncogenesis
Overexpression of the IGF2BP1 gene.
Highly cited references
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 25195122 | 2014 | IGF2BP1: a novel IGH translocation partner in B acute lymphoblastic leukemia. | 0 |
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 23069990 | 2013 | Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression? | Bell JL et al |
| 25195122 | 2014 | IGF2BP1: a novel IGH translocation partner in B acute lymphoblastic leukemia. | Gu G et al |
| 25068994 | 2014 | The role of the oncofetal IGF2 mRNA-binding protein 3 (IGF2BP3) in cancer. | Lederer M et al |
Summary
Fusion gene
IGH/IGF2BP1 IGH (14q32.33) IGF2BP1 (17q21.32) M t(14;17)(q32;q21)
Mesh
1
t(14;17)(q32;q21) G- Banding
Citation
Sarah South ; Guangyu Gu
t(14;17)(q32;q21) IGH/IGF2BP1
Atlas Genet Cytogenet Oncol Haematol. 2014-10-01
Online version: http://atlasgeneticsoncology.org/haematological/1706/new-content/gene-explorer/
