del(11q) in non-Hodgkins lymphoma (NHL)

2001-01-01   Gianluigi Castoldi , Antonio Cuneo 

1.Hematology Section, Department of Biomedical Sciences, University of Ferrara, Corso Giovecca 203, Ferrara, Italy

Clinics and Pathology

Disease

the overall incidence in NHL is 4-5%, the highest incidence having been reported in mantle cell lymphoma, where up to 70% of the cases studied by FISH may harbour a cryptic deletion in association with the classical t(11;14) translocation; FISH detects an approximate 10% incidence of 11q deletion among other histologic subsets of B-NHL; among diffuse large B-cell lymphoma the 11q- chromosome shows a preferential association with the immunoblastic variant; sensitive molecular cytogenetic methods may show 50-70% of T-cell prolymphocytic leukemia to carry an 11q deletion involving the ATM gene

Prognosis

a possible association between 11q-/ATM- and poor prognosis in B-cell NHL was reported

Cytogenetics

Cytogenetics morphological

the chromosome 11q deletion occurring in NHL most frequently affects the q22-23 bands; the 11q- anomaly occurs as a secondary change in the majority of cases

Cytogenetics molecular

because the size of the deleted segment may be beyond the resolution power of conventional banding analysis, many cases can only be detected by interphase FISH or other genetic methods using probes targeting the 11q22.3-q23.1 region

Genes Involved and Proteins

Note
the region of minimal deletion was narrowed down to a 2-3 Mb pair segment where the ataxia teleangiectasia ( ATM) gene is located; sequencing studies showed mutation in the remaining ATM allele in a significant fraction of cases

Bibliography

Pubmed IDLast YearTitleAuthors
28894851987Correlation of chromosome abnormalities with histologic and immunologic characteristics in non-Hodgkin's lymphoma and adult T cell leukemia-lymphoma. Fifth International Workshop on Chromosomes in Leukemia-Lymphoma.
108932932000Acquired chromosome 11q deletion involving the ataxia teleangiectasia locus in B-cell non-Hodgkin's lymphoma: correlation with clinicobiologic features.Cuneo A et al
105561971999Clinicopathogenetic significance of chromosomal abnormalities in patients with blastic peripheral B-cell lymphoma. Kiel-Wien-Lymphoma Study Group.Schlegelberger B et al
105562161999Molecular characterization of 11q deletions points to a pathogenic role of the ATM gene in mantle cell lymphoma.Stilgenbauer S et al
95730301998Inactivation of the ATM gene in T-cell prolymphocytic leukemias.Stoppa-Lyonnet D et al
16430181992Chromosome 11q rearrangements in B non Hodgkin's lymphoma.Vandenberghe E et al

Summary

Atlas Image
del(11q)   del(11q) G- banding (the 3 left partial karyotypes) - Courtesy Diane H. Norback, Eric B. Johnson, Sara Morrison-Delap UW Cytogenetic Services; R-banding (right) u2013 Jean Loup Huret: del(11)(q21) and ATM deletion u2013 Courtesy Hossein Mossafa

Citation

Gianluigi Castoldi ; Antonio Cuneo

del(11q) in non-Hodgkins lymphoma (NHL)

Atlas Genet Cytogenet Oncol Haematol. 2001-01-01

Online version: http://atlasgeneticsoncology.org/haematological/2020/del(11q)-in-non-hodgkins-lymphoma-(nhl)

External Links