1.FACMG, Cytogenetics Laboratory, Mayo Clinic, USA
Trisomy 18 is observed in 15-33% of lymphomas, including diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and marginal zone B-cell lymphoma (MZBCL). Trisomy 18 may be less frequent in other NHL sub-types.
Trisomy 18 is strongly associated with a t(14;18) or at least a 14q32 abnormality, and may represent a variant of the +der(18)t(14;18), which duplicates the segment 18pter-18q21. Trisomy 18 is rarely observed as the primary cytogenetic change in NHL.
Daniel L Van Dyke
+18 or trisomy 18 in lymphoproliferative disorders
Atlas Genet Cytogenet Oncol Haematol. 2003-09-01
Online version: http://atlasgeneticsoncology.org/haematological/2030/+18-or-trisomy-18-in-lymphoproliferative-disorders