t(1;2)(p22;p12) IGK/BCL10
t(1;14)(p22;q32) IGH/BCL10
2001-01-01 Gianluigi Castoldi , Antonio Cuneo
Affiliation
1.Hematology Section, Department of Biomedical Sciences, University of Ferrara, Corso Giovecca 203, Ferrara, Italy
Clinics and Pathology
Disease
the translocation is cytogenetically detectable in a minority of extranodal MALT lymphomas; irrespective of the presence of the 1;14 translocation, mutation or deletion of the BCL10 gene located at 1p22 can be detected by molecular genetic methods in 5-10% of extra-nodal MALT lymphomas, follicle centre cell lymphoma and diffuse large B-cell lymphoma; among MALT lymphoma a preferential association was noted with high-grade histology
Prognosis
in MALT lymphoma there may be an association with aggressive histology and antibiotic-unresponsive forms
Genes Involved and Proteins
Note
the breakpoints on chromosome 1p22 are located upstream of the promoter of the BCL10 gene, which shows inactivating mutations or deletions
Gene name
BCL10 (B-cell CLL/lymphoma 10)
Location
1p22.3
Protein description
322 amino acids; contains a caspase recruitment domain; role in the apoptosis
Gene name
IGH (Immunoglobulin Heavy)
Location
14q32.33
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 10845924 | 2000 | BCL10 gene mutation in lymphoma. | Du MQ et al |
| 9989495 | 1999 | Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. | Willis TG et al |
| 1728948 | 1992 | Cytogenetic study of B-cell lymphoma of mucosa-associated lymphoid tissue. | Wotherspoon AC et al |
| 10319863 | 1999 | Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32). | Zhang Q et al |
Summary
Fusion gene
IGH/BCL10 IGH (14q32.33) BCL10 (1p22.3) M t(14;18)(q32;q21) t(1;14)(p22;q32) t(3;14)(p13;q32)
Fusion gene
IGK/BCL10 IGK (14q32.33) BCL10 (1p22.3) M|IGK/BCL10 IGK (14q32.33) BCL10 (1p22.3) M t(1;2)(p22;p11)
t(1;14)(p22;q32) - Courtesy Eric Crawford, Genetics Associates, Inc., Nashville, TN 37203, USA
Citation
Gianluigi Castoldi ; Antonio Cuneo
t(1;2)(p22;p12) IGK/BCL10
t(1;14)(p22;q32) IGH/BCL10
Atlas Genet Cytogenet Oncol Haematol. 2001-01-01
Online version: http://atlasgeneticsoncology.org/haematological/2044
