del(6q) in Multiple Myeloma

1998-09-01   Christophe Brigaudeau 

1.Laboratory of Hematology, University Hospital, 87000 Limoges, France

Clinics and Pathology


multiple myeloma (MM) is a malignant plasma cell proliferation

Phenotype stem cell origin

mature differentiated B-cell, but also with CD56 expression, which is not found in normal plasma cell; CD38+, CD40+, CD138+.


MM s annual incidence is 30/106; del(6q) is observed in about 2 to 5 % of MM cases (i.e. : 5-10 % of cases with an abnormal karyotype).


bone pain; susceptibility to infections; renal failure; neurologic dysfonctions


MM staging:
- stage I: low tumour cell mass; normal Hb; low serum calcium; no bone lesion; low monoclonal Ig rate;
- stage II: fitting neither stage I nor stage II;
- stage III: high tumour cell mass; low Hb and/or high serum calcium and/or advanced lytic bone lesions and/or high monoclonal Ig rate


MM can evolve towards plasma cell leukemia


prognosis (highly variable) is according to the staging and other parameters, of which are now the karyotypic findings : two distinct cytogenetic pattern have been reported, according to the chromosome number : 1- a hyperdiploid pattern, and 2- a pattern of either pseudodiploidy,hypodiploidy or near-tetraploidy karyotypes; patients with the latter pattern appear to have a worse prognosis than patients with a hyperdiploid karyotype (med survival of 1.5 yr vs 3 yrs; p

Genes Involved and Proteins

del(6q) in MM cases encompass the 6q21 band : loss of this band suggests that the critical gene(s) might be a recessive tumour suppressor gene sitting in 6q21, which remains to be identified


Pubmed IDLast YearTitleAuthors
90546681997Cytogenetic study of 30 patients with multiple myeloma: comparison of 3 and 6 day bone marrow cultures stimulated or not with cytokines by using a miniaturized karyotypic method.Brigaudeau C et al
91159681997Cytogenetic analysis of 280 patients with multiple myeloma and related disorders: primary breakpoints and clinical correlations.Calasanz MJ et al
75371171995Improved cytogenetics in multiple myeloma: a study of 151 patients including 117 patients at diagnosis.Laï JL et al
94732401998Jumping translocations of chromosome 1q in multiple myeloma: evidence for a mechanism involving decondensation of pericentromeric heterochromatin.Sawyer JR et al
76279331995Cytogenetic findings in 200 patients with multiple myeloma.Sawyer JR et al
96394261998Chromosomal analysis in multiple myeloma: cytogenetic evidence of two different diseases.Smadja NV et al


Christophe Brigaudeau

del(6q) in Multiple Myeloma

Atlas Genet Cytogenet Oncol Haematol. 1998-09-01

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