del(17p) in non-Hodgkins lymphoma (NHL)

2000-12-01   Gianluigi Castoldi , Antonio Cuneo 

1.Hematology Section, Department of Biomedical Sciences, University of Ferrara, Corso Giovecca 203, Ferrara, Italy

Clinics and Pathology

Disease

virtually all histologic subsets of NHL may harbour a 17p- chromosome; there is variation in the reported incidence due to heterogeneity of histologic classification and to the different sensitivity of the detection methods
  • 10 to 15% of follicle centre cell lymphoma (FCCL) and mantle cell lymphomas (MCL) may carry a 17p- chromosome; minority of marginal zone B-cell lymphomas may be associated with 17p deletion
  • this anomaly is rarely found in T-cell NHL
  • Prognosis

    the 17p- chromosome was reported to predict for a poor prognosis in low grade lymphomas; any abnormality of chromosome 17 was also reported to negatively affect survival in lymphomas of all histologic grades

    Cytogenetics

    Cytogenetics morphological

  • the deleted segment may vary in size and many cases with sub-microscopic deletions involving the 17p13 band were reported by FISH; cases with unbalanced 17p translocations leading to 17p loss were also described; these cases may be associated with dicentric rearrangements
  • the 17p- is usually associated with transformation of a low-grade FCCL with t(14;18) into a high grade lymphoma; likewise, there is a higher incidence of 17p- in the blastoid variant of MCL with t(11,14) than in the typical form
  • Cytogenetics molecular

    the deletion may be detected by G or R-banding; FISH using a 17p13/p53 probe is recommended, this technique being more sensitive than conventional cytogenetics

    Genes Involved and Proteins

    Note
    the majority of cases with 17p- carry a p53 gene deletion, associated with mutation of the remaining allele; there may be a small fraction of cases with a more distal deletion involving an as yet unidentified locus

    Bibliography

    Pubmed IDLast YearTitleAuthors
    103611351999Increased number of chromosomal imbalances and high-level DNA amplifications in mantle cell lymphoma are associated with blastoid variants.Beà S et al
    27570571989Refractoriness to chemotherapy and poor survival related to abnormalities of chromosomes 17 and 7 in lymphoma.Cabanillas F et al
    100867371999Translocations involving the short arm of chromosome 17 in chronic B-lymphoid disorders: frequent occurrence of dicentric rearrangements and possible association with adverse outcome.Callet-Bauchu E et al
    93261891997Analysis of p53 gene deletions in patients with non-Hodgkin's lymphoma by dual-colour fluorescence in-situ hybridization.Clodi K et al
    111465732001Molecular cytogenetic characterization of marginal zone B-cell lymphoma: correlation with clinicopathologic findings in 14 cases.Cuneo A et al
    95576091998Identification of a commonly deleted region at 17p13.3 in leukemia and lymphoma associated with 17p abnormality.Sankar M et al
    82867481994Cytogenetic findings in peripheral T-cell lymphomas as a basis for distinguishing low-grade and high-grade lymphomas.Schlegelberger B et al
    80494241994Prognostic value of chromosomal abnormalities in follicular lymphoma.Tilly H et al

    Summary

    Note

    the 17p- chromosome is a secondary change in most cases of NHL
    Atlas Image
    del(17p)  Hybridization with the LSI p53/CEP17 and LSI p53 probes (Abbott molecular, US) showing 2 green and 2 red signals on normal metaphase (A) and only 1 red signal in metaphase and interphase cells with 17p deletion (B,C) u2013 Courtesy Adriana Zamecnikova. Insert: del(17p) G- banding u2013 Top: Courtesy Melanie Zenger and Claudia Haferlach: Bottom: u2013 Courtesy Adriana Zamecnikova.

    Citation

    Gianluigi Castoldi ; Antonio Cuneo

    del(17p) in non-Hodgkins lymphoma (NHL)

    Atlas Genet Cytogenet Oncol Haematol. 2000-12-01

    Online version: http://atlasgeneticsoncology.org/haematological/2083/del(17p)-in-non-hodgkins-lymphoma-(nhl)

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