t(3;16)(q27;p13) CIITA/BCL6

2006-03-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology


B cell non Hodgkin lymphoma (NHL)


Only 3 cases so far


The 3 patients had diffuse large B cell lymphoma (DLBCL); 2 of 2 patients were male patients, one presented with a history of follicular small cleaved cell lymphoma 15 yrs ago, when aged 47 yr. This patient died 6 mths later of progressive disease.

Genes Involved and Proteins

Gene name
BCL6 (B-Cell Lymphoma 6)
Dna rna description
spans on 25 kb;. 11 exons
Protein description
Sequence-specific DNA binding transcriptional repressor
Gene name
CIITA (MHC class II transactivator)
Protein description
Non-DNA-binding transcriptional coactivator; transactivator of the major histocompatibility complex (MHC) class II genes

Result of the Chromosomal Anomaly


5-MHC2TA/BCL6-3 fusion transcripts but also the 5-BCL6/MHC2TA-3 fusion transcripts,


Pubmed IDLast YearTitleAuthors
102334171999Concurrent chromosomal alterations at 3q27, 8q24 and 18q21 in B-cell lymphomas.Au WY et al
113804732001Detection of reciprocal fusion 5'-BCL6/partner-3' transcripts in lymphomas exhibiting reciprocal BCL6 translocations.Kaneita Y et al
115161112001Detection of translocations affecting the BCL6 locus in B cell non-Hodgkin's lymphoma by interphase fluorescence in situ hybridization.Sanchez-Izquierdo D et al
106375101999Identification of heterologous translocation partner genes fused to the BCL6 gene in diffuse large B-cell lymphomas: 5'-RACE and LA - PCR analyses of biopsy samples.Yoshida S et al


Fusion gene

CIITA/BCL6 CIITA (16p13.13) BCL6 (3q27.3) M t(3;16)(q27;p13)


Jean-Loup Huret

t(3;16)(q27;p13) CIITA/BCL6

Atlas Genet Cytogenet Oncol Haematol. 2006-03-01

Online version: http://atlasgeneticsoncology.org/haematological/2089/t(3;16)(q27;p13)-ciita-bcl6