Centroblastic lymphoma

2010-07-01   Gian Matteo Rigolin , Francesco Cavazzini , Antonio Cuneo 

1.Hematology Section, Department of Biomedical Sciences, University of Ferrara, Corso Giovecca 203, Ferrara, Italy

Clinics and Pathology

Disease

Centroblastic lymphoma is one of 3 morphologic variants of diffuse large B cell lymphoma (DLBCL). The other 2 variants are Immunoblastic lymphoma and anaplastic B-cell lymphoma.
The disease is not recognized as a separate entity in the WHO classification (2008).

Phenotype stem cell origin

The postulated normal counterpart is a germinal centre B cell or an activated post germinal centre B cell.

Epidemiology

It is the most common morphologic variant of DLBCL.

Clinics

The disease runs an aggressive course, as all DLBCL.

Pathology

The lymph node section shows an overwhelming infiltrate by medium-to-large size cells with vescicular nuclei and membrane bound nucleoli. The cytoplasm is scanty. In the majority of cases centroblasts are admixed with immunoblasts (<90%).

Treatment

Chemoimmunotherapy using anti CD20 monoclonal antibody rituximab in combination with CHOP or CHOP-like regimens is the standard of care.

Prognosis

Chemoimmunotherapy may cure 40-60% of the cases depending on age and risk factors.

Bibliography

Pubmed IDLast YearTitleAuthors
105561971999Clinicopathogenetic significance of chromosomal abnormalities in patients with blastic peripheral B-cell lymphoma. Kiel-Wien-Lymphoma Study Group.Schlegelberger B et al

Citation

Gian Matteo Rigolin ; Francesco Cavazzini ; Antonio Cuneo

Centroblastic lymphoma

Atlas Genet Cytogenet Oncol Haematol. 2010-07-01

Online version: http://atlasgeneticsoncology.org/haematological/2091/centroblastic-lymphoma

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