Centroblastic lymphoma

2010-07-01   Gian Matteo Rigolin , Francesco Cavazzini , Antonio Cuneo 

1.Hematology Section, Department of Biomedical Sciences, University of Ferrara, Corso Giovecca 203, Ferrara, Italy

Clinics and Pathology


Centroblastic lymphoma is one of 3 morphologic variants of diffuse large B cell lymphoma (DLBCL). The other 2 variants are Immunoblastic lymphoma and anaplastic B-cell lymphoma.
The disease is not recognized as a separate entity in the WHO classification (2008).

Phenotype stem cell origin

The postulated normal counterpart is a germinal centre B cell or an activated post germinal centre B cell.


It is the most common morphologic variant of DLBCL.


The disease runs an aggressive course, as all DLBCL.


The lymph node section shows an overwhelming infiltrate by medium-to-large size cells with vescicular nuclei and membrane bound nucleoli. The cytoplasm is scanty. In the majority of cases centroblasts are admixed with immunoblasts (<90%).


Chemoimmunotherapy using anti CD20 monoclonal antibody rituximab in combination with CHOP or CHOP-like regimens is the standard of care.


Chemoimmunotherapy may cure 40-60% of the cases depending on age and risk factors.


Pubmed IDLast YearTitleAuthors
105561971999Clinicopathogenetic significance of chromosomal abnormalities in patients with blastic peripheral B-cell lymphoma. Kiel-Wien-Lymphoma Study Group.Schlegelberger B et al


Gian Matteo Rigolin ; Francesco Cavazzini ; Antonio Cuneo

Centroblastic lymphoma

Atlas Genet Cytogenet Oncol Haematol. 2010-07-01

Online version: http://atlasgeneticsoncology.org/haematological/2091/centroblastic-lymphoma

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