Clinics and Pathology
Disease
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Highly cited references
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33499042 | 2021 | The MHC Class II Transactivator CIITA: Not (Quite) the Odd-One-Out Anymore among NLR Proteins. | 157 |
| 38682259 | 2024 | SARS-CoV-2 NSP5 antagonizes MHC II expression by subverting histone deacetylase 2. | 127 |
| 39035010 | 2024 | A Ménage à trois: NLRC5, immunity, and metabolism. | 113 |
| 31783769 | 2019 | Restriction factors in human retrovirus infections and the unprecedented case of CIITA as link of intrinsic and adaptive immunity against HTLV-1. | 108 |
| 25753668 | 2015 | Genome-wide CIITA-binding profile identifies sequence preferences that dictate function versus recruitment. | 81 |
| 37467968 | 2023 | The NLR member CIITA: Master controller of adaptive and intrinsic immunity and unexpected tool in cancer immunotherapy. | 80 |
| 34352044 | 2021 | EBNA2 driven enhancer switching at the CIITA-DEXI locus suppresses HLA class II gene expression during EBV infection of B-lymphocytes. | 77 |
| 33592498 | 2021 | CIITA-Transduced Glioblastoma Cells Uncover a Rich Repertoire of Clinically Relevant Tumor-Associated HLA-II Antigens. | 73 |
| 23789844 | 2013 | Histone deacetylase inhibitors activate CIITA and MHC class II antigen expression in diffuse large B-cell lymphoma. | 72 |
| 29093716 | 2017 | Tripartite Motif 22 and Class II Transactivator Restriction Factors: Unveiling Their Concerted Action against Retroviruses. | 70 |
| 22218223 | 2012 | CIITA promoter I CARD-deficient mice express functional MHC class II genes in myeloid and lymphoid compartments. | 70 |
| 38728204 | 2024 | Ciita Regulates Local and Systemic Immune Responses in a Combined rAAV-α-synuclein and Preformed Fibril-Induced Rat Model for Parkinson's Disease. | 65 |
| 39562739 | 2024 | ZBTB48 is a priming factor regulating B-cell-specific CIITA expression. | 61 |
| 39035008 | 2024 | Novel vaccination strategies based on optimal stimulation of CD4(+) T helper cells for the treatment of oral squamous cell carcinoma. | 61 |
| 37279268 | 2023 | FBXO11 constitutes a major negative regulator of MHC class II through ubiquitin-dependent proteasomal degradation of CIITA. | 56 |
| 36993983 | 2023 | Protective anti-tumor vaccination against glioblastoma expressing the MHC class II transactivator CIITA. | 56 |
| 30327417 | 2018 | Macrophage-specific MHCII expression is regulated by a remote Ciita enhancer controlled by NFAT5. | 55 |
| 38741238 | 2024 | Novel role of MHC class II transactivator in hepatitis B virus replication and viral counteraction. | 52 |
| 36304101 | 2022 | CIITA promoter polymorphism impairs monocytes HLA-DR expression in patients with septic shock. | 52 |
| 25101797 | 2014 | Common distal elements orchestrate CIITA isoform-specific expression in multiple cell types. | 51 |
| 15236650 | 2004 | Regulation of major histocompatibility complex class II gene expression in trophoblast cells. | 50 |
| 24391648 | 2013 | CIITA and Its Dual Roles in MHC Gene Transcription. | 50 |
| 21989738 | 2012 | CIITA is silenced by epigenetic mechanisms that prevent the recruitment of transactivating factors in rhabdomyosarcoma cells. | 50 |
| 38201622 | 2023 | Limited Effects of Class II Transactivator-Based Immunotherapy in Murine and Human Glioblastoma. | 48 |
| 36040405 | 2022 | BCG-Induced Tumor Immunity Requires Tumor-Intrinsic CIITA Independent of MHC-II. | 48 |
| 27089879 | 2016 | The MHC-II transactivator CIITA inhibits Tat function and HIV-1 replication in human myeloid cells. | 48 |
| 21736733 | 2011 | Molecular and cellular correlates of the CIITA-mediated inhibition of HTLV-2 Tax-2 transactivator function resulting in loss of viral replication. | 47 |
| 21890893 | 2011 | SIRT1 links CIITA deacetylation to MHC II activation. | 46 |
| 11438649 | 2001 | Self-association of CIITA and its transactivation potential. | 45 |
| 17346795 | 2007 | Role of PKCdelta in IFN-gamma-inducible CIITA gene expression. | 45 |
| 26181363 | 2015 | The class II transactivator (CIITA) is regulated by post-translational modification cross-talk between ERK1/2 phosphorylation, mono-ubiquitination and Lys63 ubiquitination. | 44 |
| 39594630 | 2024 | Non-Immune-Mediated, p27-Associated, Growth Inhibition of Glioblastoma by Class-II-Transactivator (CIITA). | 43 |
| 32855215 | 2020 | MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses. | 43 |
| 19720744 | 2009 | Regulating the activity of class II transactivator by posttranslational modifications: exploring the possibilities. | 41 |
| 28094290 | 2017 | Protein arginine methyltransferase 1 (PRMT1) represses MHC II transcription in macrophages by methylating CIITA. | 41 |
| 25366989 | 2014 | Genomic mapping of the MHC transactivator CIITA using an integrated ChIP-seq and genetical genomics approach. | 41 |
| 35760800 | 2022 | Osteocyte CIITA aggravates osteolytic bone lesions in myeloma. | 40 |
| 28286521 | 2017 | Pulling a Ligase out of a "HAT": pCAF Mediates Ubiquitination of the Class II Transactivator. | 38 |
| 21248776 | 2011 | CIITA is not associated with risk of developing rheumatoid arthritis. | 37 |
| 26833430 | 2016 | Genetic Variations of NLR family genes in Behcet's Disease. | 36 |
| 34904133 | 2022 | Low levels of CIITA and high levels of SOCS1 predict COVID-19 disease severity in children and adults. | 35 |
| 28608405 | 2017 | Revisiting the specificity of the MHC class II transactivator CIITA in classical murine dendritic cells in vivo. | 30 |
| 24036077 | 2013 | Transcriptional coactivator CIITA, a functional homolog of TAF1, has kinase activity. | 27 |
| 33604554 | 2020 | IFN-γ and CIITA modulate IL-6 expression in skeletal muscle. | 22 |
| 33777766 | 2021 | Case Report: Multiple Chromosomal Translocations Including Novel CIITA-CREBBP Fusion and Mutations in a Follicular Lymphoma. | 21 |
| 38115045 | 2023 | Differential expression of the inflammatory ciita gene may be accompanied by altered bone properties in intact sex steroid-deficient female rats. | 18 |
| 18563077 | 2008 | New dimensions of CIITA. | 13 |
| 34688128 | 2021 | Generation of a homozygous CIITA knockout iPS cell line using the CRISPR-Cas9 system. | 5 |
| 39342987 | 2024 | PDCD4 deficiency in hepatocytes exacerbates nonalcoholic steatohepatitis through enhanced MHC class II transactivator expression. | 0 |
| 16480042 | 2005 | Expression of MHC II genes. | 0 |
| 19273341 | 2009 | The dual function of the MHC class II transactivator CIITA against HTLV retroviruses. | 0 |
| 38214420 | 2024 | NLRP3 regulates CIITA/MHC II axis and interferon-γ-inducible chemokines in Malassezia globosa-infected keratinocytes. | 0 |
| 16870508 | 2006 | Epigenetic regulation of MHC-II and CIITA genes. | 0 |
| 15162420 | 2004 | Mini-review: Specificity and expression of CIITA, the master regulator of MHC class II genes. | 0 |
| 35835655 | 2022 | Novel missense variant of CIITA contributing to endometriosis. | 0 |
| 27720955 | 2016 | HIC1 epigenetically represses CIITA transcription in B lymphocytes. | 0 |
| 14734112 | 2004 | Transcriptional regulation of antigen presentation. | 0 |
| 9039770 | 1997 | Regulation of transcription of MHC class II genes. | 0 |
| 11244040 | 2001 | The bare lymphocyte syndrome and the regulation of MHC expression. | 0 |
| 11999167 | 2002 | Function and regulation of class II transactivator in the immune system. | 0 |
| 11137213 | 2000 | Transcriptional regulation of the MHC class Ib genes HLA-E, HLA-F, and HLA-G. | 0 |
| 39535369 | 2024 | Adenoviral delivery of the CIITA transgene induces T-cell-mediated killing in glioblastoma organoids. | 0 |
| 26283540 | 2015 | Polycomb recruitment at the Class II transactivator gene. | 0 |
| 33819543 | 2021 | Molecular cloning and immune characterization of CIITA in artificially challenged Chinese tongue sole (Cynoglossus semilaevis) with Vibrio harveyi. | 0 |
| 36224172 | 2023 | Identification of small molecule modulators of class II transactivator-I using computational approaches. | 0 |
| 12910265 | 2003 | CIITA-regulated plexin-A1 affects T-cell-dendritic cell interactions. | 0 |
| 25948812 | 2015 | Identification of a nuclear export sequence in the MHC CIITA. | 0 |
| 25339383 | 2015 | Molecular characterization of chicken class II transactivator gene. | 0 |
| 16210330 | 2005 | Histone acetylation regulates the cell type specific CIITA promoters, MHC class II expression and antigen presentation in tumor cells. | 0 |
| 30716531 | 2019 | Class II transactivator (CIITA) mediates IFN-γ induced eNOS repression by enlisting SUV39H1. | 0 |
| 11213800 | 2000 | Lessons from the bare lymphocyte syndrome: molecular mechanisms regulating MHC class II expression. | 0 |
| 10614003 | 1999 | The class II transactivator CIITA is a transcriptional integrator. | 0 |
| 15351782 | 2004 | T cell expression of CIITA represses Th1 immunity. | 0 |
| 16573555 | 2006 | Regulation of MHC class II expression, a unique regulatory system identified by the study of a primary immunodeficiency disease. | 0 |
| 25712539 | 2015 | Recurrent genomic rearrangements in primary testicular lymphoma. | 0 |
| 21664896 | 2011 | Epigenetic regulation of CIITA expression in human T-cells. | 0 |
| 34303919 | 2021 | Induction of CIITA by IFN-γ in macrophages involves STAT1 activation by JAK and JNK. | 0 |
| 26972221 | 2016 | The arginine methyltransferase PRMT5 regulates CIITA-dependent MHC II transcription. | 0 |
| 36223747 | 2022 | Cancer-specific T helper shared and neo-epitopes uncovered by expression of the MHC class II master regulator CIITA. | 0 |
| 33619341 | 2022 | DNA-double strand breaks enhance the expression of major histocompatibility complex class II through the ATM-NF-κΒ-IRF1-CIITA pathway. | 0 |
| 37933915 | 2024 | Interactome analysis implicates class II transactivator (CIITA) in depression and other neuroinflammatory disorders. | 0 |
| 32853948 | 2020 | Inactivating mutations of class II transactivator (CIITA) gene in gastric and colorectal cancers. | 0 |
| 25765819 | 2015 | A2b adenosine signaling represses CIITA transcription via an epigenetic mechanism in vascular smooth muscle cells. | 0 |
| 17623662 | 2007 | GTP-dependent recruitment of CIITA to the class II major histocompatibility complex promoter. | 0 |
| 23681904 | 2013 | Adenosine signaling inhibits CIITA-mediated MHC class II transactivation in lung fibroblast cells. | 0 |
| 11574280 | 2001 | The MHC class II transactivator: prey and hunter in infectious diseases. | 0 |
| 29251779 | 2018 | Selective regulation of type II interferon-inducible genes by NPM1/nucleophosmin. | 0 |
| 25862816 | 2015 | Polycomb Repressive Complex 2 Confers BRG1 Dependency on the CIITA Locus. | 0 |
| 30970129 | 2019 | Polymorphisms in the CIITA -168A/G (rs3087456) and CIITA +1614G/C (rs4774) may influence severity in multiple sclerosis patients. | 0 |
| 17991736 | 2008 | CIITA mediates interferon-gamma repression of collagen transcription through phosphorylation-dependent interactions with co-repressor molecules. | 0 |
| 16836979 | 2006 | Prolonged MHC class II expression and CIITA transcription in human keratinocytes. | 0 |
| 11464288 | 2001 | Impaired class II transactivator expression in mice lacking interferon regulatory factor-2. | 0 |
| 31870593 | 2020 | Link between CIITA rs3087456 polymorphism and the risk of laryngeal squamous cell carcinoma in a Chinese population. | 0 |
| 21050309 | 2010 | New strategies of mammary cancer vaccination. | 0 |
| 14528304 | 2003 | Enhancement of CIITA transcriptional function by ubiquitin. | 0 |
| 19041327 | 2009 | HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells. | 0 |
| 33386785 | 2024 | Novel variants in CIITA caused type II bare lymphocyte syndrome: A case report. | 0 |
| 34180145 | 2021 | CIITA gene polymorphism (rs3087456) in systemic lupus erythematosus and rheumatoid arthritis: A population-based cohort study. | 0 |
| 16703565 | 2006 | Revisiting the specificity of the MHC class II transactivator CIITA in vivo. | 0 |
| 15577315 | 2004 | Class II transactivator (CIITA) isoform expression and activity in melanoma. | 0 |
Bibliography
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Summary
Fusion gene
CIITA/??? CIITA (16p13.13) ??? ()
Note
Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to How to contribute
if you are an author who wish to write a full paper/card on this translocation,go to How to contribute
Citation
Philippe Dessen ; Jean-Loup Huret
CIITA/??? (16p13)
Atlas Genet Cytogenet Oncol Haematol. 2018-01-01
Online version: http://atlasgeneticsoncology.org/haematological/2160/ciita-(16p13)
