CDKN2A/MTAP (9p21)

2018-01-01   Philippe Dessen  , Jean-Loup Huret  

Clinics and Pathology

Disease

Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes Involved and Proteins

Gene name
Location
9p21.3
Gene name
Location
9p21.3

Highly cited references

Pubmed IDYearTitleCitations
354597882022Clinical and molecular validation of BAP1, MTAP, P53, and Merlin immunohistochemistry in diagnosis of pleural mesothelioma.70
216937302011Comprehensive field synopsis and systematic meta-analyses of genetic association studies in cutaneous melanoma.67
355654292022CD117, BAP1, MTAP, and TdT Is a Useful Immunohistochemical Panel to Distinguish Thymoma from Thymic Carcinoma.52
397622482025MAT2A inhibitor AG-270/S095033 in patients with advanced malignancies: a phase I trial.52
359122322022Genomic Features of Organ-Specific Metastases in Lung Adenocarcinoma.41
331557732020Loss of CDKN2A at chromosome 9 has a poor clinical prognosis and promotes lung cancer progression.31
378943452023Deletions of CDKN2A and MTAP Detected by Copy-Number Variation Array Are Associated with Loss of p16 and MTAP Protein in Pleural Mesothelioma.29
379090922023Early Clinical Success of MTA-Cooperative PRMT5 Inhibitors for the Treatment of CDKN2A/MTAP-Deleted Cancers.0
270684732016MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis.0
334758352021Pleural mesothelioma classification update.0
391101662024Mesothelioma: molecular pathology and biomarkers.0
200818102010CDKN2A and MTAP deletions in peritoneal mesotheliomas are correlated with loss of p16 protein expression and poor survival.0
385704222024Frequency and Nature of Genomic Alterations in ERBB2-Altered Urothelial Bladder Cancer.0
351578292022Abemaciclib in patients with p16ink4A-deficient mesothelioma (MiST2): a single-arm, open-label, phase 2 trial.0
394810342025Metastatic Mesothelioma of the Tunica Vaginalis Presenting as Scrotal and Abdominal Nodules: A Case Report and Review of the Literature.0
224933552012Molecular characterization of human cutaneous melanoma-derived cell lines.0

Article Bibliography

Pubmed IDLast YearTitleAuthors
233346682013The genomic landscape of hypodiploid acute lymphoblastic leukemia.Holmfeldt L et al

Summary

Fusion gene

CDKN2A/MTAP CDKN2A (9p21.3) MTAP (9p21.3)

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to  How to contribute

Citation

Philippe Dessen ; Jean-Loup Huret

CDKN2A/MTAP (9p21)

Atlas Genet Cytogenet Oncol Haematol. 2018-01-01

Online version: http://atlasgeneticsoncology.org/haematological/2593/cdkn2a-mtap-(9p21)