(Note: the fusion was discovered by NGS. Many chromosome rearrangement mechanisms such as translocation, inversion,deletion or complex rearrangement may lead to the same fusion)
Note
Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to u00a0How to contribute
Summary
Note
Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to How to contribute
if you are an author who wish to write a full paper/card on this translocation,go to How to contribute
Highly cited references
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34727172 | 2022 | ALK-positive histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition. | 79 |
| 36780194 | 2023 | ALK Amplification and Rearrangements Are Recurrent Targetable Events in Congenital and Adult Glioblastoma. | 65 |
| 28970558 | 2017 | Detection of known and novel ALK fusion transcripts in lung cancer patients using next-generation sequencing approaches. | 51 |
| 36915094 | 2023 | Multisystem ALK-positive histiocytosis: a multi-case study and literature review. | 38 |
| 34026599 | 2021 | Resistance Profile of Osimertinib in Pre-treated Patients With EGFR T790M-Mutated Non-small Cell Lung Cancer. | 37 |
| 26062823 | 2015 | STUMP un"stumped": anti-tumor response to anaplastic lymphoma kinase (ALK) inhibitor based targeted therapy in uterine inflammatory myofibroblastic tumor with myxoid features harboring DCTN1-ALK fusion. | 30 |
| 28167572 | 2017 | An Oncogenic ALK Fusion and an RRAS Mutation in KRAS Mutation-Negative Pancreatic Ductal Adenocarcinoma. | 28 |
| 27874193 | 2017 | ALK oncoproteins in atypical inflammatory myofibroblastic tumours: novel RRBP1-ALK fusions in epithelioid inflammatory myofibroblastic sarcoma. | 24 |
| 34964276 | 2022 | Effectiveness of alectinib and osimertinib in a brain metastasized lung adenocarcinoma patient with concurrent EGFR mutations and DCTN1-ALK fusion. | 24 |
| 29872693 | 2017 | ALK(G1269A) mutation as a potential mechanism of acquired resistance to crizotinib in an ALK-rearranged inflammatory myofibroblastic tumor. | 10 |
| 35212154 | 2022 | Response to ALK-TKIs in a lung adenocarcinoma patient harboring dual DCTN1-ALK and ALK-CLIP4 rearrangements. | 6 |
| 34014367 | 2021 | DCTN1-ALK gene fusion in inflammatory myofibroblastic tumor (IMT) of the CNS. | 0 |
| 39403984 | 2025 | Multisystem ALK-Positive Histiocytosis With DCTN1::ALK Fusion in an Adult, Responsive to Alectinib: Case Report and Literature Review. | 0 |
| 35229187 | 2022 | Spindle cell/sclerosing rhabdomyosarcoma with DCTN1::ALK fusion: broadening the molecular spectrum with potential therapeutic implications. | 0 |
| 37422156 | 2023 | Fusion-driven Spindle Cell Rhabdomyosarcomas of Bone and Soft Tissue: A Clinicopathologic and Molecular Genetic Study of 25 Cases. | 0 |
| 29437595 | 2018 | Integrated molecular profiling of juvenile myelomonocytic leukemia. | 0 |
| 33217002 | 2021 | Spindle cell variant of epithelioid cell histiocytoma (spindle cell histiocytoma) with ALK gene fusions: Cases series and review of the literature. | 0 |
| 25813404 | 2015 | Novel ALK fusion partners in lung cancer. | 0 |
| 34019866 | 2021 | Identification of novel ALK fusions using DNA/RNA sequencing in immunohistochemistry / RT-PCR discordant NSCLC patients. | 0 |
| 31880682 | 2020 | Inflammatory Myofibroblastic Tumor of the Orbit in an 8-Month Old. | 0 |
| 39565115 | 2024 | An Inflammatory Myofibroblastic Tumor With a Novel ALK(V1180L) Mutation Leading to Acquired Resistance to Tyrosine Kinase Inhibitors. | 0 |
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 24445538 | 2014 | Kinase fusions are frequent in Spitz tumours and spitzoid melanomas. | Wiesner T et al |
Citation
Jean-Loup Huret ; Philippe Dessen
t(2;2)(p13;p23) DCTN1/ALK
Atlas Genet Cytogenet Oncol Haematol. 0000-00-00
Online version: http://atlasgeneticsoncology.org/solid-tumor/105146/cookies-notice
