CAD/ALK (2p23)

0000-00-00   Jean-Loup Huret  , Philippe Dessen  

(Note: the fusion was discovered by NGS. Many chromosome rearrangement mechanisms such as translocation, inversion,deletion or complex rearrangement may lead to the same fusion)

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to u00a0How to contribute

Summary

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to  How to contribute

Genes Involved and Proteins

Gene name

Location

2p23.3

Gene name

Location

2p23.2

Highly cited references

Pubmed IDYearTitleCitations
266335602015Novel CAD-ALK gene rearrangement is drugable by entrectinib in colorectal cancer.27
261723002015Detection of novel and potentially actionable anaplastic lymphoma kinase (ALK) rearrangement in colorectal adenocarcinoma by immunohistochemistry screening.19
283684552017Tracking a CAD-ALK gene rearrangement in urine and blood of a colorectal cancer patient treated with an ALK inhibitor.14
328044542020Colorectal Adenocarcinomas Harboring ALK Fusion Genes: A Clinicopathologic and Molecular Genetic Study of 12 Cases and Review of the Literature.5

Article Bibliography

Pubmed IDLast YearTitleAuthors
266335602015Novel CAD-ALK gene rearrangement is drugable by entrectinib in colorectal cancer.Amatu A et al
269331252016Oncogenic ALK Fusion in Rare and Aggressive Subtype of Colorectal Adenocarcinoma as a Potential Therapeutic Target.Yakirevich E et al

Citation

Jean-Loup Huret ; Philippe Dessen

CAD/ALK (2p23)

Atlas Genet Cytogenet Oncol Haematol. 0000-00-00

Online version: http://atlasgeneticsoncology.org/solid-tumor/105197/cad-alk-(2p23)