(Note: the fusion was discovered by NGS. Many chromosome rearrangement mechanisms such as translocation, inversion,deletion or complex rearrangement may lead to the same fusion)
Note
Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to u00a0How to contribute
Summary
Note
Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to How to contribute
if you are an author who wish to write a full paper/card on this translocation,go to How to contribute
Highly cited references
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36754839 | 2023 | Inflammatory myofibroblastic tumor of the mesentery with a SQSTM1::ALK fusion responding to alectinib. | 33 |
| 39810398 | 2025 | Assessment of Exhaled Breath Condensate for ALK, RET, ROS1, and NTRK1 Fusion Transcript Detection in NSCLC: Comparison With Tissue and Liquid Biopsy Samples. | 33 |
| 21134980 | 2011 | Identification of a novel fusion, SQSTM1-ALK, in ALK-positive large B-cell lymphoma. | 24 |
| 29747676 | 2018 | Epithelioid cell histiocytoma with SQSTM1-ALK fusion: a case report. | 19 |
| 39651381 | 2024 | Partial Response to Treatment with ALK Inhibitor in a Patient With SQSTM1-ALK Fusion Positive Lung Adenocarcinoma. | 10 |
| 39555099 | 2024 | Case report: Treatment with ensartinib shows good response to SQSTM1-ALK fusion in lung adenocarcinoma. | 7 |
| 38266918 | 2024 | Molecular Screening in Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma: Anaplastic Lymphoma Kinase Analysis, Next-Generation Sequencing Fusion Gene Detection, and T-Cell Receptor Immunoprofiling. | 0 |
| 30790150 | 2019 | Durable response to the ALK inhibitor alectinib in inflammatory myofibroblastic tumor of the head and neck with a novel SQSTM1-ALK fusion: a case report. | 0 |
| 29327718 | 2018 | Epithelioid fibrous histiocytoma: molecular characterization of ALK fusion partners in 23 cases. | 0 |
| 23588372 | 2013 | STAT3 pathway is activated in ALK-positive large B-cell lymphoma carrying SQSTM1-ALK rearrangement and provides a possible therapeutic target. | 0 |
| 25413595 | 2015 | Epithelioid cell histiocytoma of the skin with clonal ALK gene rearrangement resulting in VCL-ALK and SQSTM1-ALK gene fusions. | 0 |
| 29329131 | 2018 | ALK Gene Fusions in Epithelioid Fibrous Histiocytoma: A Study of 14 Cases, With New Histopathological Findings. | 0 |
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 25813404 | 2015 | Novel ALK fusion partners in lung cancer. | Iyevleva AG et al |
Citation
Jean-Loup Huret ; Philippe Dessen
t(2;5)(p23;q35) SQSTM1/ALK
Atlas Genet Cytogenet Oncol Haematol. 0000-00-00
Online version: http://atlasgeneticsoncology.org/solid-tumor/105458/deep-insight-explorer/hgnc
