t(3;6)(q12;q22) TFG/ROS1

0000-00-00   Jean-Loup Huret  , Philippe Dessen  

(Note: the fusion was discovered by NGS. Many chromosome rearrangement mechanisms such as translocation, inversion,deletion or complex rearrangement may lead to the same fusion)

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to u00a0How to contribute

Summary

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to  How to contribute

Genes Involved and Proteins

Gene name

TFG

Location

3q12.2

Gene name

ROS1

Location

6q22.1

Highly cited references

Pubmed IDYearTitleCitations
386228502024Reclassification of a spindle cell sarcoma after identification of a TFG-ROS1 fusion: A case demonstrating the clinical benefit of next-generation sequencing in sarcoma.43
257231092015Molecular characterization of inflammatory myofibroblastic tumors with frequent ALK and ROS1 gene fusions and rare novel RET rearrangement.41
256125112015Expression of ROS1 predicts ROS1 gene rearrangement in inflammatory myofibroblastic tumors.38
379506262024Individualized targeted treatment in a case of a rare TFG::ROS1 fusion positive inflammatory myofibroblastic tumor (IMT).38
387879782024Two cases of inflammatory myofibroblastic tumor treated with targeted drugs: A case report.13
367300162023A Novel CASC15-ALK and TFG-ROS1 Fusion Observed in Uterine Inflammatory Myofibroblastic Tumor.0
362264722022Curable response to crizotinib in a patient with liver metastatic inflammatory myofibroblastic tumour carrying a TFG-ROS1 fusion.0
341570122021Rapid Response to Lorlatinib in a Patient With TFG-ROS1 Fusion Positive Inflammatory Myofibroblastic Tumor of the Chest Wall Metastatic to the Brain and Refractory to First and Second Generation ROS1 Inhibitors.0
340593522021Durable response to serial tyrosine kinase inhibitors (TKIs) in an adolescent with metastatic TFG-ROS1 fusion positive Inflammatory Myofibroblastic Tumor (IMT).0
320647352020Gene rearrangements in consecutive series of pediatric inflammatory myofibroblastic tumors.0
355430762022Histologic characterization of paediatric mesenchymal neoplasms treated with kinase-targeted therapy.0
266477672016ALK, ROS1 and NTRK3 gene rearrangements in inflammatory myofibroblastic tumours.0
284498092017Genomic diagnostics leading to the identification of a TFG-ROS1 fusion in a child with possible atypical meningioma.0
252939802015Adult-onset inflammatory myofibroblastic tumour of the stomach with a TFG-ROS1 fusion.0
318055292019Partial Response to Ceritinib in a Patient With Abdominal Inflammatory Myofibroblastic Tumor Carrying a TFG-ROS1 Fusion.0
316907812020Infantile inflammatory myofibroblastic tumors: clinicopathological and molecular characterization of 12 cases.0
372639292023[TFG-ROS1 fusion positive inflammatory myofibroblastoma of uterus: report of a case].0
348141852021Molecular Characterization of Inflammatory Tumors Facilitates Initiation of Effective Therapy.0
341451762021Therapeutic options in inoperable ROS1-rearranged inflammatory myofibroblastic tumor of the tongue in a child: a case report and literature review.0

Article Bibliography

Pubmed IDLast YearTitleAuthors
284498092017Genomic diagnostics leading to the identification of a TFG-ROS1 fusion in a child with possible atypical meningioma.Rossing M et al

Citation

Jean-Loup Huret ; Philippe Dessen

t(3;6)(q12;q22) TFG/ROS1

Atlas Genet Cytogenet Oncol Haematol. 0000-00-00

Online version: http://atlasgeneticsoncology.org/solid-tumor/106148/t(3;6)(q12;q22)-tfg-ros1