Fibrogenic tumors
2022-03-01 Paola Dal Cin, PhD , Judith VMG Bovée Affiliation1.Brigham and Women's Hospital , Harvard Medical School, Boston , MA (USA)
2. Leiden University Medical Center, Leiden, The Netherlands
Classification
Definition
Fibrogenic tumors are extremely rare in bone and are characterized by the production of collagenous stroma and the absence of bone and cartilage formation. Desmoplastic fibroma of bone is locally aggressive and considered to be an osseous counterpart of desmoid-type fibromatosis.
| Fibrogenic tumors | Genetic marker(s) |
|---|---|
| Desmoplastic fibroma of bone | Single cytogentic data. 1 Single cases with CTNNB1 mutation: p.Thr41Ala and p.Ser45Phe 2,3 |
| Fibrosarcoma of bone | Several chromsomal imbalances by microarray analysis , including CDKN2A (9p) homozygous loss and both STARD13 (13q) heterozygous and homozygous loss. 4 STRN::NTRK3 fusion in a single case 5 |
Article Bibliography
| Reference Number | Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|---|
| 1 | 22868002 | 2012 | Molecular genetic characterization of the 11q13 breakpoint in a desmoplastic fibroma of bone. | Trombetta D et al |
| 2 | 30159138 | 2018 | Low-grade central fibroblastic osteosarcoma may be differentiated from its mimicker desmoplastic fibroma by genetic analysis. | Song W et al |
| 3 | 31901437 | 2020 | A case of desmoplastic fibroma of bone with CTNNB1 point mutation. | Kadowaki H et al |
| 4 | 19862822 | 2010 | Frequent deletion of CDKN2A and recurrent coamplification of KIT, PDGFRA, and KDR in fibrosarcoma of bone--an array comparative genomic hybridization study. | Niini T et al |
| 5 | 30520818 | 2019 | Novel NTRK3 Fusions in Fibrosarcomas of Adults. | Yamazaki F et al |
Citation
Paola Dal Cin, PhD ; Judith VMG Bovée
Fibrogenic tumors
Atlas Genet Cytogenet Oncol Haematol. 2022-03-01
Online version: http://atlasgeneticsoncology.org/solid-tumor/208935/tumors-explorer/submit-meetings/gene-explorer/
