EBV-positive lymphoproliferative diseases of childhood
2023-06-25 Sheng Xiao, MD , Chunxiao Yang Affiliation1.Brigham and Women's Hospital , Harvard Medical School, Boston , MA (USA)
2. Brigham and Women's Hospital, Harvard Medical School, Boston , MA (USA)
Classification
Definition
EBV-positive lymphoproliferative diseases of childhood can range from benign, self-limiting conditions to more aggressive and potentially life-threatening lymphomas.1,2 EBV infection contributes to genomic instability, leading to malignant transformation. 3,4
| EBV-positive lymphoproliferative diseases of childhood | Genetic marker(s) | |
|---|---|---|
| Systemic EBV-positive T-cell lymphoma of childhood | Systemic EBV-positive T-cell lymphoma of childhood is a rapidly progressing disease characterized by multiorgan failure, sepsis, and ultimately death and is caused by the clonal proliferation of T cells infected with the EBV. There are currently no consistent chromosome or gene alterations that have been identified in association with this disease.5,6 | |
| Hydroa vacciniforme lymphoproliferative disorder | No consistent chromosome/gene alterations are described. TCR is usually clonal but does not correlate with the severity of the disease. |
Article Bibliography
| Reference Number | Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|---|
| 1 | 31833428 | 2020 | Epstein-Barr virus NK and T cell lymphoproliferative disease: report of a 2018 international meeting. | Cohen JI et al |
| 2 | 28592786 | 2017 | Epstein-Barr Virus-Associated Lymphoproliferative Disorders: Review and Update on 2016 WHO Classification. | Kim HJ et al |
| 3 | 28893938 | 2017 | Epstein-Barr virus-associated lymphomas. | Shannon-Lowe C et al |
| 4 | 27826287 | 2016 | Epstein-Barr Virus: Diseases Linked to Infection and Transformation. | Jha HC et al |
| 5 | 35330161 | 2022 | Genetic Landscape of Peripheral T-Cell Lymphoma. | Hathuc V et al |
| 6 | 30931288 | 2019 | Epstein-Barr Virus-Associated T and NK-Cell Lymphoproliferative Diseases. | Kim WY et al |
Citation
Sheng Xiao, MD ; Chunxiao Yang
EBV-positive lymphoproliferative diseases of childhood
Atlas Genet Cytogenet Oncol Haematol. 2023-06-25
Online version: http://atlasgeneticsoncology.org/solid-tumor/209170/ebv-positive-lymphoproliferative-diseases-of-childhood
