Pediatric Anaplastic large cell lymphoma
2023-06-25 Sheng Xiao, MD , Chunxiao Yang Affiliation1.Brigham and Women's Hospital , Harvard Medical School, Boston , MA (USA)
2. Brigham and Women's Hospital, Harvard Medical School, Boston , MA (USA)
Classification
Definition
Pediatric anaplastic large cell lymphoma (pALCL) is the most common subtype of pediatric mature T-cell lymphoma and is characterized by the abnormal growth of ALK-positive or ALK-negative T-cells. ALK-positive pALCL is more common and has a worse prognosis.1 Two of the common ALK rearrangements include NPM1::ALK from t(2;5)(p23;q35) and TPM3::ALK from t(1;2)(q25;p23).2 The oligomerization domain from NPM1 or TPM3 is fused to the kinase domain of ALK, leading to ligand-independent ALK activation.3-11 ALK+ ALCL respond well to next-generation ALK inhibitors such as Lorlatinib.12
Article Bibliography
| Reference Number | Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|---|
| 1 | 26913827 | 2016 | Anaplastic large cell lymphoma in paediatric and young adult patients. | Turner SD et al |
| 2 | 19545284 | 2009 | Distribution of NPM1-ALK and X-ALK fusion transcripts in paediatric anaplastic large cell lymphoma: a molecular-histological correlation. | Damm-Welk C et al |
| 3 | 9819383 | 1998 | Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity. | Bai RY et al |
| 4 | 11110708 | 2000 | Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway. | Bai RY et al |
| 5 | 17416736 | 2007 | NPM-ALK oncogenic kinase promotes cell-cycle progression through activation of JNK/cJun signaling in anaplastic large-cell lymphoma. | Leventaki V et al |
| 6 | 16909118 | 2007 | Oncogenic tyrosine kinase NPM/ALK induces activation of the MEK/ERK signaling pathway independently of c-Raf. | Marzec M et al |
| 7 | 11280786 | 2001 | Role of phosphatidylinositol 3-kinase-Akt pathway in nucleophosmin/anaplastic lymphoma kinase-mediated lymphomagenesis. | Slupianek A et al |
| 8 | 16482213 | 2006 | Fusion tyrosine kinase mediated signalling pathways in the transformation of haematopoietic cells. | Turner SD et al |
| 9 | 12934099 | 2003 | Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma. | Amin HM et al |
| 10 | 15184887 | 2004 | Selective inhibition of STAT3 induces apoptosis and G(1) cell cycle arrest in ALK-positive anaplastic large cell lymphoma. | Amin HM et al |
| 11 | 15895073 | 2005 | Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target. | Chiarle R et al |
| 12 | 35802834 | 2022 | Next-generation ALK inhibitors are highly active in ALK-positive large B-cell lymphoma. | Soumerai JD et al |
Citation
Sheng Xiao, MD ; Chunxiao Yang
Pediatric Anaplastic large cell lymphoma
Atlas Genet Cytogenet Oncol Haematol. 2023-06-25
Online version: http://atlasgeneticsoncology.org/solid-tumor/209182/pediatric-anaplastic-large-cell-lymphoma
