Pediatric acute myeloid leukemias (pAMLs) without defined recurrent genetic abnormalities are categorized based on differentiation. These leukemias can be classified into 7 subtypes: AML with minimal differentiation, AML without maturation, AML with maturation, Acute myelomonocytic leukemia, Acute monoblastic and monocytic leukemia, Pure erythroid leukemia, and Acute megakaryoblastic leukemia (AMKL).^1,2 It's important to note that this group of pAML does not include acute leukemia of ambiguous lineage, myeloid neoplasms with germline predisposition, AML with myelodysplasia-related changes, or therapy-related myeloid neoplasms. The classification is primarily based on morphological and immunophenotypic characteristics, however, genetic alterations still play a significant role in determining prognosis and guiding treatment decisions. ^3-6