Ovarian-type tumors of the collecting ducts and rete testis
2024-10-24 Andres M. Acosta, MD Affiliation1.Department of Pathology, Indiana University, Indianapolis, IN
Classification
Definition
Ovarian-type tumors of the collecting ducts and the rete testis affect mostly paratesticular tissues/structures, but may rarely occur in the testis proper. They show morphologic and immunophenotypic features akin to Mullerian counterparts. Borderline serous tumors represent the most common subtype. A subset of these serous malignant lesions show a recurrent hotspot BRA p.V600E variant. 1-3 and rarely cases with KRAS mutations with hotspot at codon 61 and 12 have also been reported. 4 A single case of clear cell adenocarcinoma has shown multiple regional and chromosomal arm-level copy number changes. 5 No specific genetic findings were identified so far in the other specific lesions in this subgroup.
Article Bibliography
| Reference Number | Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|---|
| 1 | 25491441 | 2015 | The V600E BRAF mutation in a borderline serous tumour of the testis is genotypic evidence of similarity with its phenotypic ovarian counterpart. | Cundell D et al |
| 2 | 26197800 | 2015 | Ovarian-type epithelial tumours of the testis: immunohistochemical and molecular analysis of two serous borderline tumours of the testis. | Bürger T et al |
| 3 | 28543997 | 2017 | The mutational frequency of BRAF and KRAS in low-grade serous testicular neoplasms-a case series. | Gwiti P et al |
| 4 | 33062370 | 2020 | KRAS Mutation in Serous Borderline Tumor of the Testis: Report of a Case and Review of the Literature. | Bouri S et al |
| 5 | 38409850 | 2024 | Genomic analysis of primary epithelial neoplasms of the seminal vesicle identifies a subset of mucinous cystic tumours driven by KRAS mutations. | Collins K et al |
Citation
Andres M. Acosta, MD
Ovarian-type tumors of the collecting ducts and rete testis
Atlas Genet Cytogenet Oncol Haematol. 2024-10-24
Online version: http://atlasgeneticsoncology.org/solid-tumor/209281/ovarian-type-tumors-of-the-collecting-ducts-and-rete-testis
