Optic nerve gliomas/Optic pathway gliomas  (OPGS) of childhood are most found in patients with NF1.  ^1-3
The most frequent sporadic tumor is pilocytic astrocytomas (PA) which most frequently (~60%) exhibits a tandem ~2Mb duplication of chromosome 7q34, resulting in KIAA1549::BRAF fusion. ⁴ Additional BRAF gene partners have also been identified, all resulting in loss of the N-terminal regulatory region of the BRAF protein, with retention of the kinase domain. ⁵ Activating BRAF (p.V600E) mutations has been reported in ~10-15% of cases. ⁶
See more details in the CNS pediatric tumors section of WHO2022 Paediatric tumours , as well as on WHO WHO2021 Central nervous system tumours.