Hereditary factors can contribute to the development of tumors of tumors involving the head and neck. A significant number of patients with inherited tumors manifest disease that appears to be sporadic disease even in some syndromic cases. Virtually all these disorders have now been characterized at the molecular level.  Constitutional pathogenetic variants can now be routinely screened by next generation sequencing (NGS) to identify at-risk individuals in affected families, and offer genetic counseling, choice of therapy and surveillance guideline.  There is a wide range of hereditary genetic disorders that are associated with familiar predisposition to a variety of head and neck tumors neoplasms. ¹