Nasal, paranasal and skull base tumors
2025-07-17 Paola Dal Cin, PhD Affiliation1.Brigham and Women's Hospital , Harvard Medical School, Boston , MA (USA)
Classification
Definition
There are several entities that occur exclusively or predominantly in the sinonasal tract region and demonstrate a diverse genetic landscape and varying clinical courses. 1-3 Genetic studies, as well as, the availability of more specific and sensitive immunohistochemical antibodies have led to better understanding and more accurate classification of the lesions in the sinonasal tract region , based on specific genetic alterations e.g., DEK::AFF2, BRD4::NUTM1 ETV6::NTRK3. PAX3::MAML3, protein expression e.g., Beta-catenin, specific gene mutation e.g., CTNNB1, IDH2, SMARCB1, SMARCA4, TBXT, BRAF or infection by oncogenic viruses e.g., EBV, HPV. 4,5
Article Bibliography
| Reference Number | Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|---|
| 1 | 32725435 | 2020 | Novel Biomarkers in Sinonasal Cancers: from Bench to Bedside. | Lechner M et al |
| 2 | 35312976 | 2022 | Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Nasal Cavity, Paranasal Sinuses and Skull Base. | Thompson LDR et al |
| 3 | 37591773 | 2023 | Update from the 5th Edition of the WHO Classification of Nasal, Paranasal, and Skull Base Tumors: Imaging Overview with Histopathologic and Genetic Correlation. | Agarwal A et al |
| 4 | 36753024 | 2023 | Translocations and Gene Fusions in Sinonasal Malignancies. | Larkin R et al |
| 5 | 38491228 | 2024 | Molecularly defined sinonasal malignancies: an overview with focus on the current WHO classification and recently described provisional entities. | Skálová A et al |
Citation
Paola Dal Cin, PhD
Nasal, paranasal and skull base tumors
Atlas Genet Cytogenet Oncol Haematol. 2025-07-17
Online version: http://atlasgeneticsoncology.org/solid-tumor/209324/nasal-paranasal-and-skull-base-tumors
