Classic Hodgkin lymphoma is a B-lineage lymphoma with distinctive features: the neoplastic cells (Reed-Sternberg cells and variants) are unusually large and atypical, express CD30 and often CD15, and have lost expression of most B-cell associated antigens, except for PAX5.  In addition, there is a microenvironment composed of a mix of reactive leukocytes which usually greatly outnumber the neoplastic cells. Nodular lymphocyte predominant Hodgkin lymphoma typically has a distinctive nodular architecture, neoplastic “LP cells” with distinctive morphology, and a reactive component that consists of lymphocytes and histiocytes. Hodgkin lymphoma only rarely involves extranodal sites in the head and neck, ¹ but lymph node involvement is common.