Non-neoplastic lesions

2025-12-04   Paola Dal Cin, PhD 

1.Brigham and Women's Hospital , Harvard Medical School, Boston , MA (USA)

Keywords
Oral non-neoplastic lesions, HPV, Heck's disease

Classification

Definition

This non-neoplastic section included : 1)  Necrotizing sialometaplasia , a relatively rare destructive and inflammatory lesion of the minor salivary glands on the hard palate; 1 2) Multifocal epithelial hyperplasia , also known as Heck's disease, a benign squamous epithelial proliferation caused by HPV, mainly subtypes 13 and 32, although other genotypes have also been detected,2,3 and oral melanoacanthoma a rare, mixed epithelial pigmented lesion  mostly seen among blacks and more frequently in younger females.4

Article Bibliography

Reference NumberPubmed IDLast YearTitleAuthors
1367216152022Necrotizing Sialometaplasia: A Diagnostic Challenge to Oral Physicians.Senthilnathan N et al
2335019852022An update on Heck's disease-a systematic review.Sethi S et al
3391192982024Multifocal epithelial hyperplasia: an understudied infectious disease affecting ethnic groups. A mini review.Conde-Ferráez L et al
4359897462022Multifocal Intraoral Melanoacanthomas: Two Case Reports and a Literature Review.Aljanobi HA et al

Citation

Paola Dal Cin, PhD

Non-neoplastic lesions

Atlas Genet Cytogenet Oncol Haematol. 2025-12-04

Online version: http://atlasgeneticsoncology.org/solid-tumor/209356/non-neoplastic-lesions