Many inherited tumor syndromes have cutaneous manifestations providing critical insights into the important interaction of the genome with the environment, as mediated by genetic susceptibility and dramatically demonstrated by the extreme sensitivity to ultraviolet (UV) radiation seen in xeroderma pigmentosum. The table below contains selected major and well-characterized inherited syndromes specifically associated with malignant tumors of the skin. 

However, there are many benign skin neoplasms encountered that can be associated with tumors with other inherited tumor syndromes , including syndromes associated with internal malignancies. ^1,2 See details in (2023) WHO Skin Tumours .