PIP4K2A is a lipid kinase that phosphorylates phosphatidylinositol (PtdIns) 5P, generating PtdIns4,5P2, which is an important precursor to second messengers of the phosphoinositide signal transduction pathways. Recently, studies have indicated that PIP4K2A is involved in the regulation of important biological processes that participate in the malignant phenotype, including cell proliferation, clonogenicity and survival. The present review on PIP4K2A contains data on DNA\/RNA, protein encoded and where the gene is implicated.
Symbol
Protein
DNA
vs. P. troglodytes
PIP4K2A
100
99.9
vs. M. mulatta
98.7
vs. C. lupus
91.8
vs. B. taurus
99.3
92.6
vs. M. musculus
Pip4k2a
98.3
89.5
vs. R. norvegicus
97.5
87.9
vs. G. gallus
93.6
84.5
vs. X. tropicalis
pip4k2b
93.2
80.9
vs. D. rerio
pip4k2aa
87.6
76.8
NCBI: 5305 MIM: 603140 HGNC: 8997 Ensembl: ENSG00000150867 AllianceGenome:
dbSNP: 5305 ClinVar: 5305 TCGA: ENSG00000150867 COSMIC: PIP4K2A
Keli Lima ; Joao Agostinho Machado-Neto
PIP4K2A (phosphatidylinositol-5-phosphate 4-kinase, type II, alpha)
Atlas Genet Cytogenet Oncol Haematol. 2015-09-01
Online version: http://atlasgeneticsoncology.org/gene/43943/pip4k2a