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Centroblastic lymphoma

Written2010-07Antonio Cuneo, Gian Matteo Rigolin, Francesco Cavazzini
Hematology Section, Department of Biomedical Sciences, University of Ferrara, Corso Giovecca 203, Ferrara, Italy

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Clinics and Pathology

Disease Centroblastic lymphoma is one of 3 morphologic variants of diffuse large B cell lymphoma (DLBCL). The other 2 variants are Immunoblastic lymphoma and anaplastic B-cell lymphoma.
The disease is not recognized as a separate entity in the WHO classification (2008).
Phenotype / cell stem origin The postulated normal counterpart is a germinal centre B cell or an activated post germinal centre B cell.
The immunophenotype may help distinguishing germinal centre-derived DLBCL from activated B-cell derived DLBCL, the former being CD10+ (>30% of the cells), or BCL6+ and IRF4/MUM1-.
The immunophenotype reproduces that of DLBCL, with pan B-cell markers positive, surface and/or cytoplasmic Ig positive in the majority of the cases. The CD30 antigen is negative. CD5 is positive in 10% of the cases. CD10 is expressed in approximately half of the cases.
Epidemiology It is the most common morphologic variant of DLBCL.
Clinics The disease runs an aggressive course, as all DLBCL.
Pathology The lymph node section shows an overwhelming infiltrate by medium-to-large size cells with vescicular nuclei and membrane bound nucleoli. The cytoplasm is scanty. In the majority of cases centroblasts are admixed with immunoblasts (<90%).
Treatment Chemoimmunotherapy using anti CD20 monoclonal antibody rituximab in combination with CHOP or CHOP-like regimens is the standard of care.
Prognosis Chemoimmunotherapy may cure 40-60% of the cases depending on age and risk factors.


Cytogenetics Molecular Because the distinction from other morphologic variants of DLBCL is not reproducible it is generally accepted that there are no distinctive cytogenetic or molecular features with respect to diffuse large B-cell lymphoma.
However, some authors described a more frequent occurrence of the t(14;18) than in immunoblastic lymphoma (Schlegelberger et al., 1999).


Clinicopathogenetic significance of chromosomal abnormalities in patients with blastic peripheral B-cell lymphoma. Kiel-Wien-Lymphoma Study Group.
Schlegelberger B, Zwingers T, Harder L, Nowotny H, Siebert R, Vesely M, Bartels H, Sonnen R, Hopfinger G, Nader A, Ott G, Muller-Hermelink K, Feller A, Heinz R.
Blood. 1999 Nov 1;94(9):3114-20.
PMID 10556197
Diffuse large B-cell lymphoma, not otherwise specified.
Stein H, Warnke RA, Chan WC, Jaffe ES, Chan JKC, Gatter KC, Campo E.
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, ed. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. WHO press, 4th ed. Lyon: IARC. 2008; pp 233-237.


This paper should be referenced as such :
Cuneo, A ; Rigolin, GM ; Cavazzini, F
Centroblastic lymphoma
Atlas Genet Cytogenet Oncol Haematol. 2011;15(4):355-355.
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