1.Department of Pathology Centro di Riferimento Oncologico Aviano (CRO), Istituto Nazionale Tumori, IRCCS, Aviano, Italy; acarbone@cro.it (AC); Department of Diagnostic Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy; annunziata.gloghini@istitutotumori.mi.it (AG)2.Department of Pathology Centro di Riferimento Oncologico Aviano (CRO), Istituto Nazionale Tumori, IRCCS, Aviano, Italy; acarbone@cro.it (AC); Department of Diagnostic Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy; annunziata.gloghini@istitutotumori.mi.it (AG)
Over the past 50 years, a relevant progress has been made toward our understanding of classical Hodgkin lymphoma pathology and cell biology. Histologic classification evolved through different systems to the 2008 World Health Organization classification, upgraded in 2016.
Hodgkin lymphoma subtype
EBV infection
HL of the general population
Nodular lymphocyte predominance
Absent
cHL, nodular sclerosis
Usually absent *
cHL, mixed cellularity
Usually present *
Rare types
cHL, lymphocyte rich
Variably present
cHL, lymphocyte depleted
HIV-associated HL
Present
Less frequent
cHL, lymphohistiocyoid
Post-transplant (cHL type PTLD)
Similar to other cHL
Iatrogenic (methotrexate)
Variably present (usually present)
Abbreviations. cHL, classical Hodgkin lymphoma; PTLD, post-transplant lymphoproliferative disorder*Association with EBV is less frequent in ns (10-40%) than in mc cHL (approximately 75% of cases).
Annunziata Gloghini ; Antonino Carbone
Mixed cellularity classical Hodgkin lymphoma (MCcHL)
Atlas Genet Cytogenet Oncol Haematol. 2016-06-01
Online version: http://atlasgeneticsoncology.org/haematological/1566/mixed-cellularity-classical-hodgkin-lymphoma-(mcchl)