| Disease |
Chronic or acute myeloid malignancies and lymphoid neoplasms. |
| Note |
See also i(5)(p10) in acute myeloid leukemia |
| Etiology | 38 patients (20 M/18 F aged 8 to 86 years; median 69 years). Myeloid malignancies mainly (26 patients): 18 AML, 7 MDS and 1 CML. In 10 of the 18 AML patients the cells were of monoblastic (8 patients)/monocytic (2 patients) lineage. Among them, 4 had therapy-related MDS, 1 had therapy-related AML (t-MDS/t-AML), and one patient had chronic myelogenous leukemia in myeloid blast phase. The primary diagnoses for patients with t-MDS/t-AML were mediastinal germ cell tumor (Christodoulou et al., 2004), carcinoma of the ovary (Lessard et al., 2007), breast carcinoma (Gervais et al., 2008) and multiple myeloma (Jimenez-Sousa et al., 2010; Reddi et al., 2012). The occurrence of i(5)(p10 was not restricted to myeloid malignancies as it was also detected in 8 patients with B-cell and in 3 with T-cell lymphoid malignancies. |
| Epidemiology | Chronic myeloproliferative disorders (MPD) in 8 (4M/4F aged 19 to 81 years; median 66 years): 1 chronic myeloid leukemia (Markovic et al., 2000) and 7 MDS (Christodoulou et al., 2004; Lessard et al., 2007; Herry et al., 2010; Jimenez-Sousa et al., 2010; Douet-Guilbert et al., 2011; Reddi et al., 2012; Giudici et al., 2013).
Acute myeloid leukemia (AML) in 18 (9M/9F aged 8 to 86 years, median 64 years): 2 AML (Flach et al., 2011; Hartmann et al.,2014), 2 acute myeloblastic leukemia without maturation (M1) (Calabrese et al., 2000; Choi et al., 2007), 2 acute myeloblastic leukemia with maturation (M2) (Tamura et al., 1998; Herry et al., 2007), 1 acute promyelocytic leukemia (M3) (Goldschmidt et al., 2010), 2 acute myelomonocytic leukemia (M4) (El-Rifai et al., 1997; Panani 2006), 8 acute monoblastic leukemia (M5) (Yunis 1984; Slovak et al., 1991; Schoch et al 2001; Schmidt et al., 2004; Gervais et al., 2008; Paar et al., 2013) and 1 acute erythroleukemia (M6) (Herry et al., 2010) patient.
Multiple myeloma was diagnosed in a single male (Sawyer et al., 2014).
Lymphoid malignancies in 12 patients. B-cell lymphomas in 7 (3M/4F aged 55, 71, 78 and 86 years, 3 unknown) (Hashimoto et al., 1995; Dierlamm et al., 1997; Wlodarska et al., 1999; Hernandez et al., 2001; Bastard et al., 1992; Cook et al., 2004; Johnson et al., 2008), and there was a 54-years old male with chronic lymphocytic leukemia (Jarosova et al., 2010). 3 patients were diagnosed with T-cell lymphoid malignancies (2M/1F aged 38 and 69 years, 1 unknown) (Heinonen et al., 1994; Lepretre et al., 2000; Nelson et al., 2008) and an 11- years old male with bilineage or biphenotypic leukemia (La Starza et al., 1993). |
| Prognosis | i(5)(p10 is frequently part of complex karyotypes representing clonal evolution that may reflect genomic instability. Most of these patients showed a more aggressive course of the disease and poor response to chemotherapy (Paar et al., 2013). |
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