Disease |
Chronic or acute myeloid malignancies and lymphoid neoplasms. |
Note |
See also i(5)(p10) in acute myeloid leukemia |
Etiology | 38 patients (20 M/18 F aged 8 to 86 years; median 69 years). Myeloid malignancies mainly (26 patients): 18 AML, 7 MDS and 1 CML. In 10 of the 18 AML patients the cells were of monoblastic (8 patients)/monocytic (2 patients) lineage. Among them, 4 had therapy-related MDS, 1 had therapy-related AML (t-MDS/t-AML), and one patient had chronic myelogenous leukemia in myeloid blast phase. The primary diagnoses for patients with t-MDS/t-AML were mediastinal germ cell tumor (Christodoulou et al., 2004), carcinoma of the ovary (Lessard et al., 2007), breast carcinoma (Gervais et al., 2008) and multiple myeloma (Jimenez-Sousa et al., 2010; Reddi et al., 2012). The occurrence of i(5)(p10 was not restricted to myeloid malignancies as it was also detected in 8 patients with B-cell and in 3 with T-cell lymphoid malignancies. |
Epidemiology | Chronic myeloproliferative disorders (MPD) in 8 (4M/4F aged 19 to 81 years; median 66 years): 1 chronic myeloid leukemia (Markovic et al., 2000) and 7 MDS (Christodoulou et al., 2004; Lessard et al., 2007; Herry et al., 2010; Jimenez-Sousa et al., 2010; Douet-Guilbert et al., 2011; Reddi et al., 2012; Giudici et al., 2013). Acute myeloid leukemia (AML) in 18 (9M/9F aged 8 to 86 years, median 64 years): 2 AML (Flach et al., 2011; Hartmann et al.,2014), 2 acute myeloblastic leukemia without maturation (M1) (Calabrese et al., 2000; Choi et al., 2007), 2 acute myeloblastic leukemia with maturation (M2) (Tamura et al., 1998; Herry et al., 2007), 1 acute promyelocytic leukemia (M3) (Goldschmidt et al., 2010), 2 acute myelomonocytic leukemia (M4) (El-Rifai et al., 1997; Panani 2006), 8 acute monoblastic leukemia (M5) (Yunis 1984; Slovak et al., 1991; Schoch et al 2001; Schmidt et al., 2004; Gervais et al., 2008; Paar et al., 2013) and 1 acute erythroleukemia (M6) (Herry et al., 2010) patient. Multiple myeloma was diagnosed in a single male (Sawyer et al., 2014). Lymphoid malignancies in 12 patients. B-cell lymphomas in 7 (3M/4F aged 55, 71, 78 and 86 years, 3 unknown) (Hashimoto et al., 1995; Dierlamm et al., 1997; Wlodarska et al., 1999; Hernandez et al., 2001; Bastard et al., 1992; Cook et al., 2004; Johnson et al., 2008), and there was a 54-years old male with chronic lymphocytic leukemia (Jarosova et al., 2010). 3 patients were diagnosed with T-cell lymphoid malignancies (2M/1F aged 38 and 69 years, 1 unknown) (Heinonen et al., 1994; Lepretre et al., 2000; Nelson et al., 2008) and an 11- years old male with bilineage or biphenotypic leukemia (La Starza et al., 1993). |
Prognosis | i(5)(p10 is frequently part of complex karyotypes representing clonal evolution that may reflect genomic instability. Most of these patients showed a more aggressive course of the disease and poor response to chemotherapy (Paar et al., 2013). |
Maximizing mailed questionnaire responses |
Baker CM |
Image J Nurs Sch 1985 Fall;17(4):118-21 |
PMID 3852770 |
|
Karyotype refinement in five patients with acute myeloid leukemia using spectral karyotyping |
Calabrese G, Fantasia D, Spadano A, Morizio E, Di Bartolomeo P, Palka G |
Haematologica 2000 Nov;85(11):1219-21 |
PMID 11064476 |
|
C/EBPbeta suppression by interruption of CUGBP1 resulting from a complex rearrangement of MLL |
Choi WT, Folsom MR, Azim MF, Meyer C, Kowarz E, Marschalek R, Timchenko NA, Naeem RC, Lee DA |
Cancer Genet Cytogenet 2007 Sep;177(2):108-14 |
PMID 17854664 |
|
Myelodysplastic syndrome (RARS) with +i(12p) abnormality in a patient 10 months after diagnosis and successful treatment of a mediastinal germ cell tumor (MGCT) |
Christodoulou J, Schoch C, Schnittger S, Haferlach T |
Ann Hematol 2004 Jun;83(6):386-9 |
PMID 14615911 |
|
Isolated 5p isochromosome in myelodysplastic syndrome: report of the first case |
Douet-Guilbert N, Basinko A, De Braekeleer E, Guéganic N, Bovo C, Le Bris MJ, Morel F, Eveillard JR, Berthou C, Herry A, De Braekeleer M |
Leuk Res 2011 Nov;35(11):e193-7 |
PMID 21803421 |
|
Chromosomal breakpoints and changes in DNA copy number in refractory acute myeloid leukemia |
El-Rifai W, Elonen E, Larramendy M, Ruutu T, Knuutila S |
Leukemia 1997 Jul;11(7):958-63 |
PMID 9204975 |
|
An accumulation of cytogenetic and molecular genetic events characterizes the progression from MDS to secondary AML: an analysis of 38 paired samples analyzed by cytogenetics, molecular mutation analysis and SNP microarray profiling |
Flach J, Dicker F, Schnittger S, Schindela S, Kohlmann A, Haferlach T, Kern W, Haferlach C |
Leukemia 2011 Apr;25(4):713-8 |
PMID 21233836 |
|
Interstitial insertion of RARα gene into PML gene in a patient with acute promyelocytic leukemia (APL) lacking the classic t(15;17) |
Goldschmidt N, Yehuda-Gafni O, Abeliovich D, Slyusarevsky E, Rund D |
Hematology 2010 Oct;15(5):332-7 |
PMID 20863428 |
|
Isochromosome 5p and related anomalies: a novel recurrent chromosome abnormality in myeloid disorders |
Herry A, Douet-Guilbert N, Morel F, Le Bris MJ, Guéganic N, Berthou C, De Braekeleer M |
Cancer Genet Cytogenet 2010 Jul 15;200(2):134-9 |
PMID 20620596 |
|
Quit wasting time with "nursing rituals" |
Huttmann B |
Nursing 1985 Oct;15(10):34-9 |
PMID 3850404 |
|
Myelodysplastic syndrome with isochromosome 5p and trisomy 8 after treatment of a multiple myeloma |
Jimenez-Sousa MA, Ferro MT, Talavera M, Villalon C, Cabello P, Laraña J, Herrera P, Garcia Sagredo JM |
Cancer Genet Cytogenet 2010 Dec;203(2):345-7 |
PMID 21156257 |
|
Fluorescence in situ hybridization analysis of 110 hematopoietic disorders with chromosome 5 abnormalities: do de novo and therapy-related myelodysplastic syndrome-acute myeloid leukemia actually differ? Cancer Genet Cytogenet |
Lessard M, Hélias C, Struski S, Perrusson N, Uettwiller F, Mozziconacci MJ, Lafage-Pochitaloff M, Dastugue N, Terré C, Brizard F, Cornillet-Lefebvre P, Mugneret F, Barin C, Herry A, Luquet I, Desangles F, Michaux L, Verellen-Dumoulin C, Perrot C, Van den Akker J, Lespinasse J, Eclache V, Berger R; Groupe Francophone de Cytogénétique Hématologique |
2007 Jul 1;176(1):1-21 |
PMID 17574959 |
|
Lack of BCR/ABL reciprocal fusion in variant Philadelphia chromosome translocations: a use of double fusion signal FISH and spectral karyotyping |
Markovic VD, Bouman D, Bayani J, Al-Maghrabi J, Kamel-Reid S, Squire JA |
Leukemia 2000 Jun;14(6):1157-60 |
PMID 10865986 |
|
Gain of an isochromosome 5p: a rare recurrent abnormality in acute myeloid leukemia |
Panani AD |
In Vivo 2006 May-Jun;20(3):359-60 |
PMID 16724670 |
|
Myeloid neoplasms secondary to plasma cell myeloma: an intrinsic predisposition or therapy-related phenomenon? A clinicopathologic study of 41 cases and correlation of cytogenetic features with treatment regimens |
Reddi DM, Lu CM, Fedoriw G, Liu YC, Wang FF, Ely S, Boswell EL, Louissaint A Jr, Arcasoy MO, Goodman BK, Wang E |
Am J Clin Pathol 2012 Dec;138(6):855-66 |
PMID 23161720 |
|
RT-PCR and FISH analysis of acute myeloid leukemia with t(8;16)(p11;p13) and chimeric MOZ and CBP transcripts: breakpoint cluster region and clinical implications |
Schmidt HH, Strehl S, Thaler D, Strunk D, Sill H, Linkesch W, Jäger U, Sperr W, Greinix HT, König M, Emberger W, Haas OA |
Leukemia 2004 Jun;18(6):1115-21 |
PMID 15085163 |
|
Gain of an isochromosome 5p: a new recurrent chromosome abnormality in acute monoblastic leukemia |
Schoch C, Bursch S, Kern W, Schnittger S, Hiddemann W, Haferlach T |
Cancer Genet Cytogenet 2001 May;127(1):85-8 |
PMID 11408074 |
|
Acute monoblastic leukemia (FAB-M5b) with t(8;14)(p11;q11 |
Slovak ML, Nemana L, Traweek ST, Stroh JA |
1) Cancer Genet Cytogenet |
PMID 1756469 |
|
Cytogenetic analysis of de novo acute myeloid leukemia with trilineage myelodysplasia in comparison with myelodysplastic syndrome evolving to acute myeloid leukemia |
Tamura S, Takemoto Y, Hashimoto-Tamaoki T, Mimura K, Sugahara Y, Senoh J, Furuyama JI, Kakishita E |
Int J Oncol 1998 Jun;12(6):1259-62 |
PMID 9592183 |
|
Recurrent chromosomal defects are found in most patients with acute nonlymphocytic leukemia |
Yunis JJ |
Cancer Genet Cytogenet 1984 Feb;11(2):125-37 |
PMID 6692334 |
|