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i(8)(q10) in acute myeloid leukaemia

Written2007-03David Betts
Department of Oncology, University Children's Hospital, Steinwiesstr. 75, CH-8032 Zò_rich, Switzerland

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ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
Atlas_Id 1334
  i(8)(q10)  i(8)(q10) TOP: G- banding (left) - Courtesy Melanie Zenger and Claudia Haferlach; R-banding: middle - Courtesy Jean Luc Lai; right Jean Loup Huret. Hybridization with the Vysis LSI RUNX1/RUNX1T1 probes showing extra copies of RUNX1T1 as a result of isochromosome i(8)(q10) (A) and + i(8)(q10) (B) formation (red signals) - Courtesy Adriana Zamecnikova.

Clinics and Pathology

Disease Acute myeloid leukaemia (AML)
Note The aberration has also been reported in many other neoplastic disorders, most notably T-prolymphocytic leukaemia (PLL) and acute lymphoblastic leukaemia (ALL). In the latter, it often occurs as a secondary event to the t(9;22).
Phenotype / cell stem origin Has been reported to occur in all AML FAB types, with FAB M2 representing the most common morphology.
Epidemiology A rare non-random event reported in over 50 cases of AML (below 0.5% of all cases) and occurs in both children and adults.
Prognosis As the aberration is rare and will frequently occur in complex karyotypes, whether an independent prognosis association can be determined is uncertain.


Cytogenetics Morphological In approximately 40% of cases the aberration is reported as a chromosome gain.
Additional anomalies Seldom occurs as a primary karyotype event. Most often found in complex karyotypes and/or arises in a sub-clone. The complex karyotypes will frequently contain loss of chromosome 5(q) and/or loss of chromosome 7(q).


Cross-species color banding in ten cases of myeloid malignancies with complex karyotypes.
Harrison CJ, Yang F, Butler T, Cheung KL, O'Brien PC, Hennessy BJ, Prentice HG, Ferguson-Smith M
Genes, chromosomes & cancer. 2001 ; 30 (1) : 15-24.
PMID 11107171
Comparative genomic hybridization and conventional cytogenetic analyses in childhood acute myeloid leukemia.
Huhta T, Vettenranta K, Heinonen K, Kanerva J, Larramendy ML, Mahlamäki E, Saarinen-Pihkala UM, Knuutila S
Leukemia & lymphoma. 1999 ; 35 (3-4) : 311-315.
PMID 10706455
Loss of i(8)(q10) at relapse in two cases of childhood acute myeloid leukaemia.
Seppa L, Hengartner H, Leibundgut K, Kuhne T, Niggli FK, Betts DR
Leukemia & lymphoma. 2007 ; 48 (5) : 1045-1047.
PMID 17487754
Deletions of the long arm of chromosome 7 in myeloid disorders: loss of band 7q32 implies worst prognosis.
Velloso ER, Michaux L, Ferrant A, Hernandez JM, Meeus P, Dierlamm J, Criel A, Louwagie A, Verhoef G, Boogaerts M, Michaux JL, Bosly A, Mecucci C, Van den Berghe H
British journal of haematology. 1996 ; 92 (3) : 574-581.
PMID 8616020
Isochromosome 8q is a marker of secondary acute myeloid leukemia.
Wong KF, Kwong YL
Cancer genetics and cytogenetics. 2000 ; 120 (2) : 171-173.
PMID 10991616


This paper should be referenced as such :
Betts, D
i(8)(q10) in acute myeloid leukaemia
Atlas Genet Cytogenet Oncol Haematol. 2007;11(3):245-246.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Translocations implicated (Data extracted from papers in the Atlas)

 i(8)(q10) in acute myeloid leukaemia

External links

Mitelman databasei(8)(q10)
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9861/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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