Disease |
Acute myeloid leukaemia (AML) |
Note |
The aberration has also been reported in many other neoplastic disorders, most notably T-prolymphocytic leukaemia (PLL) and acute lymphoblastic leukaemia (ALL). In the latter, it often occurs as a secondary event to the t(9;22). |
Phenotype / cell stem origin |
Has been reported to occur in all AML FAB types, with FAB M2 representing the most common morphology. |
Epidemiology | A rare non-random event reported in over 50 cases of AML (below 0.5% of all cases) and occurs in both children and adults. |
Prognosis | As the aberration is rare and will frequently occur in complex karyotypes, whether an independent prognosis association can be determined is uncertain. |
Cross-species color banding in ten cases of myeloid malignancies with complex karyotypes. |
Harrison CJ, Yang F, Butler T, Cheung KL, O'Brien PC, Hennessy BJ, Prentice HG, Ferguson-Smith M |
Genes, chromosomes & cancer. 2001 ; 30 (1) : 15-24. |
PMID 11107171 |
|
Comparative genomic hybridization and conventional cytogenetic analyses in childhood acute myeloid leukemia. |
Huhta T, Vettenranta K, Heinonen K, Kanerva J, Larramendy ML, Mahlamäki E, Saarinen-Pihkala UM, Knuutila S |
Leukemia & lymphoma. 1999 ; 35 (3-4) : 311-315. |
PMID 10706455 |
|
Loss of i(8)(q10) at relapse in two cases of childhood acute myeloid leukaemia. |
Seppa L, Hengartner H, Leibundgut K, Kuhne T, Niggli FK, Betts DR |
Leukemia & lymphoma. 2007 ; 48 (5) : 1045-1047. |
PMID 17487754 |
|
Deletions of the long arm of chromosome 7 in myeloid disorders: loss of band 7q32 implies worst prognosis. |
Velloso ER, Michaux L, Ferrant A, Hernandez JM, Meeus P, Dierlamm J, Criel A, Louwagie A, Verhoef G, Boogaerts M, Michaux JL, Bosly A, Mecucci C, Van den Berghe H |
British journal of haematology. 1996 ; 92 (3) : 574-581. |
PMID 8616020 |
|
Isochromosome 8q is a marker of secondary acute myeloid leukemia. |
Wong KF, Kwong YL |
Cancer genetics and cytogenetics. 2000 ; 120 (2) : 171-173. |
PMID 10991616 |
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