Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

t(1;7)(p32;q34) TRB/TAL1

t(1;14)(p32;q11) TRA/TAL1

1p32 rearrangements

Written1998-01Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9837/3 T lymphoblastic leukaemia/lymphoma
Atlas_Id 1047
Note the two chromosome anomalies are variants of each other, and they share identical features
 
  t(1;14)(p32;q11) ) G-banding (left)- Courtesy Diane H. Norback, Eric B. Johnson, and Sara Morrison-Delap, UW Cytogenetic Services and R-banding (right) - Courtesy Isabelle Radford-Weiss

Clinics and Pathology

Disease T- cell ALL
Epidemiology rare findings; t(1;14) is found in approximately 3% of T-ALL; t(1;7) is rarer (status 3: < 5 cases); however, TAL1 rearrangements, all together (being mostly submicroscopic deletions without visible 1p32 involvement), occurs in 15-25% of T-ALL; male predominance (as is classical in T-cell ALL)
Clinics organomegaly; high WBC (median 200X 109/l)

Cytogenetics

Additional anomalies t(1;14) is found solely in about half cases, and accompanied by del(6q) in nearly half cases as well

Genes involved and Proteins

Gene Name TAL1
Location 1p32
Dna / Rna complex alternate splicing
Protein contains a basic Helix-Loop-Helix (DNA binding) domain; forms heterodimers; transcription factor; role in haematopoietic cell differentiation
Gene Name TRA
Location 14q11 in the case of a t(1;14)
Gene Name TRB
Location 7q35 in the case of a t(1;7)

Result of the chromosomal anomaly

Fusion Protein
 
Description in most cases (breakpoints between exons 2B and 3 of TAL1), 3' TAL1 joins variable and diversity segments of TCR on der(14); in the few cases where the breakpoint is within exon 6 of TAL1 or 3' from it, constant segments of TCR join TAL1 on der(1)
  

Bibliography

Clinical features and outcome of T-cell acute lymphoblastic leukemia in childhood with respect to alterations at the TAL1 locus: a Pediatric Oncology Group study.
Bash RO, Crist WM, Shuster JJ, Link MP, Amylon M, Pullen J, Carroll AJ, Buchanan GR, Smith RG, Baer R
Blood. 1993 ; 81 (8) : 2110-2117.
PMID 8471769
 

Citation

This paper should be referenced as such :
Huret, JL
t(1;7)(p32;q34)
Atlas Genet Cytogenet Oncol Haematol. 1998;2(1):20-21.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/t0114ID1047.html


Other genes implicated (Data extracted from papers in the Atlas) [ 4 ]

Genes TAL1 TRA TRB TRD

Translocations implicated (Data extracted from papers in the Atlas)

 t(1;14)(p32;q11) TRA/TAL1
 t(1;7)(p32;q34) TRB/TAL1

External links

Mitelman databaset(1;14)(p32;q11) [Case List]    t(1;14)(p32;q11) [Association List] Mitelman database (CGAP - NCBI)
Mitelman databaset(1;7)(p32;q34) [Case List]    t(1;7)(p32;q34) [Association List] Mitelman database (CGAP - NCBI)
arrayMapTopo ( C42) Morph ( 9837/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databaset(1;7)(p32;q34) TRB/TAL1
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 12 11:18:03 CET 2017


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.