t(3;6)(q27;p21)
2009-08-01 Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
Non Hodgkin lymphoma (NHL).
Epidemiology
Seven cases available: 3 cases of follicular lymphoma (FL), 3 cases of diffuse large B-cell lymphoma (DLBCL), and one NHL not otherwise specified. Very few data available: 4 male / 2 female patients, aged 49-79 years (Ohno et al., 1994; Miura et al., 1996; Yoshida et al., 1999; Chen et al., 2001; Varga et al., 2001; Keller et al., 2006).
Genes Involved and Proteins
Gene name
BCL6 (B-Cell Lymphoma 6)
Location
3q27.3
Protein description
706 amino acids; composed of a NH2-term BTB/POZ domain (amino acids 1-130 (32-99 according to Swiss-Prot)) which mediates homodimerization and protein-protein interactions with other corepressors (including HDAC1 and NCOR2/SMRT) to constitute a large repressing complex, another transcription repression domain (191-386), PEST sequences (300-417) with a KKYK motif (375-379), and six zinc finger at the C-term (518-541, 546-568, 574-596, 602-624, 630-652, 658-681), responsible for sequence specific DNA binding. Transcription repressor; recognizes the consensus sequence: TTCCT(A/C)GAA (Albagli-Curiel, 2003).
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 12555064 | 2003 | Ambivalent role of BCL6 in cell survival and transformation. | Albagli-Curiel O et al |
| 11579468 | 2001 | Splicing factor SRP20 is a novel partner of BCL6 in a t(3;6)(q27;p21) translocation in transformed follicular lymphoma. | Chen W et al |
| 16867873 | 2006 | Intrachromosomal rearrangement of chromosome 3q27: an under recognized mechanism of BCL6 translocation in B-cell non-Hodgkin lymphoma. | Keller CE et al |
| 8923787 | 1996 | A new non-random chromosomal translocation t(3;6)(q27;p21.3) associated with BCL6 rearrangement in two patients with non-Hodgkin's lymphoma. | Miura I et al |
| 8063612 | 1994 | Heterogeneity in B-cell neoplasms associated with rearrangement of the LAZ3 gene on chromosome band 3q27. | Ohno H et al |
| 11303527 | 2001 | Clustering of 1p36 breakpoints distal to 1p36.2 in hematological malignancies. | Varga AE et al |
| 10637510 | 1999 | Identification of heterologous translocation partner genes fused to the BCL6 gene in diffuse large B-cell lymphomas: 5'-RACE and LA - PCR analyses of biopsy samples. | Yoshida S et al |
Summary
Note
In only two cases were the hybrid genes uncovered: a PIM1/BCL6 was found in one case (Yoshida et al., 1999), and a SFRS3/BCL6 in another case (Chen et al., 2001). These cases will also be described separately.
Citation
Jean-Loup Huret
t(3;6)(q27;p21)
Atlas Genet Cytogenet Oncol Haematol. 2009-08-01
Online version: http://atlasgeneticsoncology.org/haematological/2155/t(3;6)(q27;p21)
