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t(3;8)(q27;q24) BCL6::MYC

Written2008-03Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

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Atlas_Id 2015
  t(3;8)(q27;q24) BCL6/MYC Hybridization with Vysis LSI BCL6 break apart probe (Abbott Molecular, US) showing rearrangement of the gene as a result of t(3;8)(q27;q24) (red signal on der(8) chromosome). Hybridization with Vysis LSI BCL6 break apart and LSI IGH/BCL dual color probes (Abbott Molecular, US) showing rearrangement of BCL6 and IGH as a result of a 3-way t(3;8;14)(q27;q24;q32) - Courtesy Adriana Zamecnikova.

Clinics and Pathology

Disease Non Hodgkin lymphoma (NHL)
Phenotype / cell stem origin Found in diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL)
Epidemiology 4 cases to date, three cases of DLBCL and one BL. There was 1 male and 3 female patients. Patients were in their fifties (53, 53, and 56 years), apart from an eleven year old patient, but the latter was affected by a cancer-prone disease/chromosome instability syndrome, namely an ataxia telangiectasia (AT).
Clinics The t(3;8) may be considered as a secondary event in two DLBCL cases harbouring a t(14;18) (Bertrand et al, 2007). In the third case of DLBCL, the disease was thought to have evolved from a follicular lymphoma, also present in the patient in various organs (Wang et al, 2007). To be noted that the patient with a BL had AT (Sandlund et al, 2006).
Prognosis Prognostic data were available from only two of the four cases, with survivals noted at: 26+ mths and 114+ mths (in two DLBCL cases).


Cytogenetics Morphological Major karyotypic abnormalities in 3 of 4 cases, with +7 in two patients, +12 in two cases, t(14;18)(q32;q21) in two cases, and duplication of the der(8)t(3;8) in two cases; Other anomalies known to be recurrent in lymphoid malignancies were also present: del(6q) (one case), and +18 (one case).

Genes involved and Proteins

Gene NameBCL6 (B-Cell Lymphoma 6)
Location 3q27.3
Protein Transcription factor, with a N-term BTB/POZ domain and 6 zinc fingers. The protein can bind to sequence specific DNA and repress its transcription. Normally expressed in germinal center B and T cells
Gene NameMYC v-myc myelocytomatosis viral oncogene homolog (avian)
Location 8q24.21
Protein Transcription factor, with a DNA binding domain, a helix-loop-helix domain and a leucine zipper. Forms heterodimers with MAX; MYC/MAX complexes bind DNA, activate transcription and promote cell proliferation and transformation.

Result of the chromosomal anomaly

Hybrid gene
Description 5' BCL6 is translocated next to MYC on the der(8)

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.


Mapping of MYC breakpoints in 8q24 rearrangements involving non-immunoglobulin partners in B-cell lymphomas.
Bertrand P, Bastard C, Maingonnat C, Jardin F, Maisonneuve C, Courel MN, Ruminy P, Picquenot JM, Tilly H.
Leukemia. 2007 Mar;21(3):515-23.
PMID 17230227
A subtle t(3;8) results in plausible juxtaposition of MYC and BCL6 in a child with Burkitt lymphoma/leukemia and ataxia-telangiectasia.
Sandlund JT, Kastan MB, Kennedy W, Behm F, Entrekin E, Pui CH, Kalwinsky DT, Raimondi SC.
Cancer Genet Cytogenet. 2006 Jul 1;168(1):69-72.
PMID 16772123
A novel t(3;8)(q27;q24.1) simultaneously involving both the BCL6 and MYC genes in a diffuse large B-cell lymphoma.
Wang HY, Bossler AD, Schaffer A, Tomczak E, DiPatri D, Frank DM, Nowell PC, Bagg A.
Cancer Genet Cytogenet. 2007 Jan 1;172(1):45-53.
PMID 17175379


This paper should be referenced as such :
Huret, JL
Atlas Genet Cytogenet Oncol Haematol. 2009;13(3):235-236.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Other genes implicated (Data extracted from papers in the Atlas) [ 1 ]

Genes BCL6

Translocations implicated (Data extracted from papers in the Atlas)

 t(3;8)(q27;q24) BCL6/MYC

External links

Mitelman databaset(3;8)(q27;q24)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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