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t(3;14)(p14;q32) IGH::FOXP1

Written2005-07Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France

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Atlas_Id 1398

Clinics and Pathology

Disease Extra-nodal Marginal Zone B-cell lymphoma (MZBCL) of mucosa-associated lymphoid tissue (MALT) type, also called MALT lymphoma
Note MALT lymphomas without the t(3;14) are frequently associated with either a t(1;14)(p22;q32) ( BCL10 / IGH), a t(11;18)(q21;q21) ( API2 / MALT1, or a t(14;18)(q32;q21) (IGH/MALT1)
Epidemiology 9 cases detected to date
Clinics MALT lymphoma is an indolent disease involving most often the stomach, the lung, the thyroid, the salivary gland, the orbit, and the skin, with a non random anatomic distribution according to the translocation. The t(3;14) is frequently found in MALT lymphomas of the thyroid, the orbit, and the skin.


Additional anomalies +3 is found in half cases

Genes involved and Proteins

Gene NameFOXP1 (Forkhead box P1)
Location 3p13
Protein Transcription factor; member of the FOXP subfamily, characterized by a DNA binding forkhead.
Gene NameIGH (Immunoglobulin Heavy)
Location 14q32.33

Result of the chromosomal anomaly

Hybrid gene
Description Breakpoint upstream the first 5' non coding exon of FOXP1

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.


T(3;14)(p14.1;q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphoma.
Streubel B, Vinatzer U, Lamprecht A, Raderer M, Chott A
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2005 ; 19 (4) : 652-658.
PMID 15703784


This paper should be referenced as such :
Huret, JL
Atlas Genet Cytogenet Oncol Haematol. 2005;9(4):327-327.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Other genes implicated (Data extracted from papers in the Atlas) [ 1 ]

Genes FOXP1

Translocations implicated (Data extracted from papers in the Atlas)

 t(3;14)(p14;q32) IGH/FOXP1

External links

IGH (14q32.33) FOXP1 (3p13)

Mitelman databaset(3;14)(p14;q32)
arrayMap (UZH-SIB Zurich)[select an item]
Mitelman databaseIGH::FOXP1 [MCList]  IGH (14q32.33) FOXP1 (3p13)
REVIEW articlesautomatic search in PubMed
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