| Identity |
| Note | This data is extracted from a very large study from an International Workshop on treatment related leukemias - restricted to balanced chromosome aberrations (i.e.: -5/del(5q)and -7/del(7q) not taken into account per see), published in Genes,Chromosomes and Cancer in 2002. |
| Clinics and Pathology |
| Disease | Treatment related myelodysplasia (t-MDS) or acute non lymphocytic leukaemias (t-ANLL) |
| Note | The study included 9 cases; t-MDS with progression to ANLL accounted for 1 of 9 cases, and t-ANLL for the remaining 8 cases; no case of acute lymphoblastic leukaemia |
| Epidemiology | t(8;16)(p11;p13) was found in 2% of t-MDS/t-ANLL; sex ratio: 5M/4F |
| Clinics | Age at diagnosis of the primary disease 33 yrs (range 6-70); age at diagnosis of the t-MDS/t-ANLL: 41 yrs (range 7-71). Median interval was 17 mths (range: 13-202). Primary disease was a solid tumor in 9 of 9 cases; treatment was radiotherapy in 1 case, chemotherapy in 2 of 9 cases, or both (6/9). Treatment included topoisomerase II inhibitors in 6 of 8 cases and alkylating agents in 7/8. |
| Prognosis | Median survival was very poor: 5 mths, with 39% of patients surviving at 1 yr, and none at 2 yrs. |
| Cytogenetics |
| Additional anomalies | Complex karyotypes were found in 4 of 9 cases. |
| Result of the chromosomal anomaly |
| Description | 5' MOZ -3Õ CBP |
| External links |
| Other database | t(8;16)(p11;p13) in treatment related leukemia | Mitelman database (CGAP - NCBI) | |
| Other database | t(8;16)(p11;p13) in treatment related leukemia | CancerChromosomes (NCBI) |
| Bibliography |
| Rare recurring balanced chromosome abnormalities in therapy-related myelodysplastic syndromes and acute leukemia: report from an international workshop. |
| Block AW, Carroll AJ, Hagemeijer A, Michaux L, van Lom K, Olney HJ, Baer MR |
| Genes, chromosomes & cancer. 2002 ; 33 (4) : 401-412. |
| PMID 11921274 |
| Contributor(s) |
| Written | 10-2003 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(8;16)(p11;p13) in treatment related leukemia. Atlas Genet Cytogenet Oncol Haematol. October 2003 . URL : http://AtlasGeneticsOncology.org/Genes/t0816p11p13TreatRelID1302.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Fri Sep 5 17:09:51 2008 |
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