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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
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t(11;14)(q13;q32) IGH/CCND1


Note t(11;14) is mainly found in mantle cell lymphoma, but also in B-prolymphocytic leukaemia, in plasma cell leukaemia, in splenic lymphoma with villous lymphocytes, in chronic lymphocytic leukaemia, and in multiple myeloma, herein briefly described; all these diseases involve a B-lineage lymphocyte.
  t(11;14)(q13;q32) Top: G- banding - Courtesy Diane H. Norback, Eric B. Johnson, Sara Morrison-Delap Cytogenetics at theWaisman Center and R- banding: Third row - Editor; last row and FISH - Courtesy Hossein Mossafa.

Clinics and Pathology

Disease mantle cell lymphoma
Phenotype / cell stem origin B-cell non Hodgkin lymphoma of the low to intermediate grade
Epidemiology annual incidence 5/106; median age: 65 yrs
Clinics advanced disease
Prognosis median survival: 3 to 4 yrs

Disease B-prolymphocytic leukaemia
Phenotype / cell stem origin chronic lymphoproliferative disorder affecting mature B-cells
Epidemiology rare disease; median age 70 yrs
Clinics patients often present with advanced stage disease
Prognosis median survival: 3 yrs

Disease plasma cell leukaemia
Phenotype / cell stem origin proliferation involving plasma cells
Epidemiology rare disorder
Prognosis median survival is less than a yr

Disease splenic lymphoma with villous lymphocytes
Phenotype / cell stem origin chronic B-cell lymphoproliferation
Epidemiology rare disorder; median age: 70 yrs
Clinics relatively benign clinical course
Prognosis 80% 5-yr survival

Disease chronic lymphocytic leukaemia
Phenotype / cell stem origin chronic B-cell lymphoproliferation
Epidemiology annual incidence 30/106; median age: 60-80 yrs
Clinics often a slow evolutive disease
Prognosis highly variable according to the staging: from staging A: survival not reduced compared to age matched population, to staging C: median survival of 2 yrs

Disease multiple myeloma
Phenotype / cell stem origin malignant plasma cell proliferation (terminally differenciated B-cell)
Epidemiology annual incidence: 30/106; median age: 60 yrs
Prognosis median survival: 3 yrs.


Cytogenetics Morphological t(11;14) has earlier been thought to be the hallmark of the mantle cell lymphoma; actually, the frequency of t(11;14) is: 50-70% in mantle cell lymphoma, 10-20% in B-prolymphocytic leukaemia, in plasma cell leukaemia, and in splenic lymphoma with villous lymphocytes, and 2-5% in chronic lymphocytic leukaemia, and in multiple myeloma.
Cytogenetics Molecular in particular interphase cytogenetics, are relevant in these diseases with an usually low mitotic index
Additional anomalies sole anomaly in only 10% of cases; part of a complex karyotype in 2/3 of cases; numerous recurrent anomalies found conjointly (which is the primary?), particularly: +3, +7, del(9p), +18, + mar, found in about 10% of cases each; other: del(1p), del(6q), del(7q), -8, +12, del(13q), del(17p)
Variants three way complex t(11;14; Var) exist and showed that the crucial event lies on der(14)

Genes involved and Proteins

Gene Name BCL1
Location 11q13
Dna / Rna 5 exons
Protein encodes the cyclin D1; role in the cell cycle control: G1 progression and G1/S transition
Gene Name IGH
Location 14q32

Result of the chromosomal anomaly

Hybrid gene
Description 5' BCL1 translocated on chromosome 14 near JH (junctions genes of IgH) and C in 3'; the breakpoint in BCL1 is in MTC (major translocation cluster), centromeric to the gene (in 5'), in 80% of cases, or dispersed in mTC1, 2, or 3 in 5'of the gene or in the 3' untranslated region of exon 5.
Fusion Protein
Description no fusion protein, but promoter exchange; the immunoglobulin gene enhancer stimulates the expression of BCL1
Oncogenesis overexpression of BCL1 accelerates passage through the G1 phase.

Other genes implicated (Data extracted from papers in the Atlas)


Translocations implicated (Data extracted from papers in the Atlas)

 t(11;14)(q13;q32) IGH/CCND1

External links

Mitelman database
t(11;14)(q13;q32) - Mitelman database (CGAP - NCBI)


Rearrangement and overexpression of the BCL-1/PRAD-1 gene in intermediate lymphocytic lymphomas and in t(11q13)-bearing leukemias.
Rimokh R, Berger F, Delsol G, Charrin C, Berthˆ©as MF, Ffrench M, Garoscio M, Felman P, Coiffier B, Bryon PA
Blood. 1993 ; 81 (11) : 3063-3067.
PMID 8499640
Overexpression of the PRAD1 oncogene in a patient with prolymphocytic leukemia with t(11;14)(q13;q32).
Kobayashi H, Kitano K, Saito H, Aoki K, Narita A, Terada N, Sonoyama M, Uchimaru K, Machii T, Motokura T
Cancer genetics and cytogenetics. 1995 ; 84 (1) : 69-72.
PMID 7497446
The ultrastructure of mantle cell lymphoma and other B-cell disorders with translocation t(11;14)(q13;q32).
Resnitzky P, Matutes E, Hedges M, Morilla R, Brito-Babapulle V, Khokhar T, Catovsky D
British journal of haematology. 1996 ; 94 (2) : 352-361.
PMID 8759896
Genes and chromosomes in chronic B-cell leukemia.
Crossen PE
Cancer genetics and cytogenetics. 1997 ; 94 (1) : 44-51.
PMID 9078290
Cytogenetics of lymphomas: a brief review of its theoretical and practical significance.
Donner LR
Cancer genetics and cytogenetics. 1997 ; 94 (1) : 20-26.
PMID 9078287
Cytogenetics and molecular genetics in multiple myeloma.
Feinman R, Sawyer J, Hardin J, Tricot G
Hematology/oncology clinics of North America. 1997 ; 11 (1) : 1-25.
PMID 9081201
Prognostic factors in chronic lymphocytic leukemia.
Hallek M, Kuhn-Hallek I, Emmerich B
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1997 ; 11 Suppl 2 : S4-13.
PMID 9178831
Mantle cell lymphoma: diagnostic criteria, clinical aspects and therapeutic problems.
Meusers P, Hense J, Brittinger G
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1997 ; 11 Suppl 2 : S60-S64.
PMID 9178843
Overexpression of PRAD1/cyclin D1 in plasma cell leukemia with t(11;14)(q13;q32).
Shimazaki C, Goto H, Araki S, Tatsumi T, Takahashi R, Hirai H, Kikuta T, Yamagata N, Ashihara E, Inaba T, Fujita N, Suzuki R, Nakagawa M
International journal of hematology. 1997 ; 66 (1) : 111-115.
PMID 9220667
Mantle cell lymphoma: presenting features, response to therapy, and prognostic factors.
Bosch F, Lˆ„pez-Guillermo A, Campo E, Ribera JM, Conde E, Piris MA, Vallespˆ‚ T, Woessner S, Montserrat E
Cancer. 1998 ; 82 (3) : 567-575.
PMID 9452276
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed


Written05-1998Jean-Loup Huret


This paper should be referenced as such :
Huret, JL
Atlas Genet Cytogenet Oncol Haematol. 1998;2(4):129-131.
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