Written | 2003-02 | Jean-Loup Huret |
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France |
Identity |
ICD-Topo | C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
ICD-Morpho | 9920/3 Therapy-related myeloid neoplasms |
ICD-Morpho | 9989/3 Myelodysplastic syndrome, unclassifiable |
Atlas_Id | 1270 |
Clinics and Pathology |
Disease | Treatment related myelodysplastic syndrome (MDS) evolving towards acute myeloid leukemia |
Etiology | the patient experienced a mantle cell lymphoma 52 mths before diagnosis of MDS |
Epidemiology | only one case to date, a 56 yr old male patient |
Cytogenetics |
Cytogenetics Morphological | sole anomaly |
Genes involved and Proteins |
Note | The gene in 15q22 is yet unknown, and, because cryptic t(12;21) ETV6 /AML1 are not rare, it is therefore uncertain whether this translocation involve a new AML1 partner |
Gene Name | RUNX1 (runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene)) |
Location | 21q22.12 |
Dna / Rna | transcription is from telomere to centromere |
Protein | contains a Runt domain and, in the C-term, a transactivation domain; forms heterodimers; widely expressed; nuclear localisation; transcription factor (activator) for various hematopoietic-specific genes |
To be noted |
Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
Bibliography |
Novel cryptic, complex rearrangements involving ETV6-CBFA2 (TEL-AML1) genes identified by fluorescence in situ hybridization in pediatric patients with acute lymphoblastic leukemia. |
Mathew S, Shurtleff SA, Raimondi SC |
Genes, chromosomes & cancer. 2001 ; 32 (2) : 188-193. |
PMID 11550288 |
CBFA2(AML1) translocations with novel partner chromosomes in myeloid leukemias: association with prior therapy. |
Roulston D, Espinosa R 3rd, Nucifora G, Larson RA, Le Beau MM, Rowley JD |
Blood. 1998 ; 92 (8) : 2879-2885. |
PMID 9763573 |
Citation |
This paper should be referenced as such : |
Huret, JL |
t(15;21)(q22;q22) |
Atlas Genet Cytogenet Oncol Haematol. 2003;7(2):120-120. |
Free journal version : [ pdf ] [ DOI ] |
On line version : http://AtlasGeneticsOncology.org/Anomalies/t1521q22q22ID1270.html |
Translocations implicated (Data extracted from papers in the Atlas) |
t(15;21)(q22;q22) RUNX1/? | |
External links |
REVIEW articles | automatic search in PubMed |
Last year articles | automatic search in PubMed |
All articles | automatic search in PubMed |
© Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Dec 14 18:26:42 CET 2020 |
For comments and suggestions or contributions, please contact us