Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

+22 or trisomy 22 (solely?)

Written2000-02Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)


ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
Atlas_Id 1042
Note +22 is often associated with inv(16)(p13q22) or its equivalents; the existence of trisomy 22 solely is debated

Clinics and Pathology

Disease acute myeloid leukemia (AML)
Phenotype / cell stem origin M4eo AML most often in cases associated with inv(16); M4 also, but only in 2/3 of cases ,when +22 is apparently without inv(16); and eosinophilia may be missing in the latter case
Epidemiology young age, both in cases with or without inv(16)
Clinics inv(16) may be at increased CNS relapse when +22 is also present
Prognosis a fair prognosis is associated with +22 accompanying inv(16), and with +22 solely, comparable to the prognosis associated with inv(16)


Cytogenetics Morphological +22 is a frequent anomaly additional to inv(16), but was not found associated with other anomalies recurrently found in de novo AML; +22 may also occur apparently in the absence of inv(16), but cryptic rearrangements of MYH11 (16p13) and CBFB (16q22) have been found in a number of cases; for some authors, +22 indicates the obligate existence of an inv(16); for others +22 solely is a true entity
Cytogenetics Molecular is appropriate to exclude or discover the presence of a hidden inv(16), inasmuch as inv(16) is associated with a relatively good prognosis
Additional anomalies anomalies associated with +22 are del(7q) and/or +8, found in15% of cases each; this percentage is similar in cases with or without inv(16)


Is trisomy 22 in acute myeloid leukemia a primary abnormality or only a secondary change associated with inversion 16?
Grois N, Nowotny H, Tyl E, Krieger O, Kier P, Haas OA
Cancer genetics and cytogenetics. 1989 ; 43 (1) : 119-129.
PMID 2790767
Secondary chromosomal abnormalities in acute leukemias.
Johansson B, Mertens F, Mitelman F
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1994 ; 8 (6) : 953-962.
PMID 8207990
A study to determine whether trisomy 8, deleted 9q and trisomy 22 are markers of cryptic rearrangements of PML/RARalpha, AML1/ETO and CBFB/MYH11 respectively in acute myeloid leukaemia. MRC Adult Leukaemia Working Party. Medical Research Council.
Langabeer SE, Grimwade D, Walker H, Rogers JR, Burnett AK, Goldstone AH, Linch DC
British journal of haematology. 1998 ; 101 (2) : 338-340.
PMID 9609531
Acute myelomonocytic leukemia with abnormal eosinophils and inv(16) or t(16;16) has a favorable prognosis.
Larson RA, Williams SF, Le Beau MM, Bitter MA, Vardiman JW, Rowley JD
Blood. 1986 ; 68 (6) : 1242-1249.
PMID 3465376
Central nervous system involvement in acute nonlymphocytic leukemia with inv(16)(p13q22).
Ohyashiki K, Ohyashiki JH, Iwabuchi A, Ito H, Toyama K
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1988 ; 2 (6) : 398-399.
PMID 3163744
Trisomy 22 in acute myeloid leukemia: a marker for myeloid leukemia with monocytic features and cytogenetically cryptic inversion 16.
Wong KF, Kwong YL
Cancer genetics and cytogenetics. 1999 ; 109 (2) : 131-133.
PMID 10087946


This paper should be referenced as such :
Huret, JL
+22 or trisomy 22 (solely?)
Atlas Genet Cytogenet Oncol Haematol. 2000;4(1):19-19.
Free journal version : [ pdf ]   [ DOI ]
On line version :

External links

arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9861/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Oct 8 16:40:21 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us