+22 or trisomy 22 (solely?)

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+22 or trisomy 22 (solely?)

Identity

Note +22 is often associated with inv(16)(p13q22) or its equivalents; the existence of trisomy 22 solely is debated

Clinics and Pathology

Disease acute non lymphocytic leukemia (ANLL)

Phenotype / cell stem origin M4eo ANLL most often in cases associated with inv(16); M4 also, but only in 2/3 of cases ,when +22 is apparently without inv(16); and eosinophilia may be missing in the latter case

Epidemiology young age, both in cases with or without inv(16)

Clinics inv(16) may be at increased CNS relapse when +22 is also present

Prognosis a fair prognosis is associated with +22 accompanying inv(16), and with +22 solely, comparable to the prognosis associated with inv(16)

Cytogenetics

Cytogenetics Morphological +22 is a frequent anomaly additional to inv(16), but was not found associated with other anomalies recurrently found in de novo ANLL; +22 may also occur apparently in the absence of inv(16), but cryptic rearrangements of MYH11 (16p13) and CBFB (16q22) have been found in a number of cases; for some authors, +22 indicates the obligate existence of an inv(16); for others +22 solely is a true entity

Cytogenetics Molecular is appropriate to exclude or discover the presence of a hidden inv(16), inasmuch as inv(16) is associated with a relatively good prognosis

Additional anomalies anomalies associated with +22 are del(7q) and/or +8, found in15% of cases each; this percentage is similar in cases with or without inv(16)

External links

Other database +22 or trisomy 22 (solely?) Mitelman database (CGAP - NCBI)

Other database	+22 or trisomy 22 (solely?)	Mitelman database (CGAP - NCBI)

Bibliography

Acute myelomonocytic leukemia with abnormal eosinophils and inv(16) or t(16;16) has a favorable prognosis.

Larson RA, Williams SF, Le Beau MM, Bitter MA, Vardiman JW, Rowley JD

Blood. 1986 ; 68 (6) : 1242-1249.

PMID 3465376

Central nervous system involvement in acute nonlymphocytic leukemia with inv(16)(p13q22).

Ohyashiki K, Ohyashiki JH, Iwabuchi A, Ito H, Toyama K

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1988 ; 2 (6) : 398-399.

PMID 3163744

Is trisomy 22 in acute myeloid leukemia a primary abnormality or only a secondary change associated with inversion 16?

Grois N, Nowotny H, Tyl E, Krieger O, Kier P, Haas OA

Cancer genetics and cytogenetics. 1989 ; 43 (1) : 119-129.

PMID 2790767

Secondary chromosomal abnormalities in acute leukemias.

Johansson B, Mertens F, Mitelman F

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1994 ; 8 (6) : 953-962.

PMID 8207990

A study to determine whether trisomy 8, deleted 9q and trisomy 22 are markers of cryptic rearrangements of PML/RARalpha, AML1/ETO and CBFB/MYH11 respectively in acute myeloid leukaemia. MRC Adult Leukaemia Working Party. Medical Research Council.

Langabeer SE, Grimwade D, Walker H, Rogers JR, Burnett AK, Goldstone AH, Linch DC

British journal of haematology. 1998 ; 101 (2) : 338-340.

PMID 9609531

Trisomy 22 in acute myeloid leukemia: a marker for myeloid leukemia with monocytic features and cytogenetically cryptic inversion 16.

Wong KF, Kwong YL

Cancer genetics and cytogenetics. 1999 ; 109 (2) : 131-133.

PMID 10087946

Contributor(s)

Written 02-2000 Jean-Loup Huret

Citation

This paper should be referenced as such :
Huret JL . +22 or trisomy 22 (solely?). Atlas Genet Cytogenet Oncol Haematol. February 2000 .
URL : http://AtlasGeneticsOncology.org/Anomalies/tri22ID1042.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon May 12 18:13:27 2008

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j.l.huret@chu-poitiers.fr.

Disease	acute non lymphocytic leukemia (ANLL)
Phenotype / cell stem origin	M4eo ANLL most often in cases associated with inv(16); M4 also, but only in 2/3 of cases ,when +22 is apparently without inv(16); and eosinophilia may be missing in the latter case
Epidemiology	young age, both in cases with or without inv(16)
Clinics	inv(16) may be at increased CNS relapse when +22 is also present
Prognosis	a fair prognosis is associated with +22 accompanying inv(16), and with +22 solely, comparable to the prognosis associated with inv(16)

Cytogenetics Morphological	+22 is a frequent anomaly additional to inv(16), but was not found associated with other anomalies recurrently found in de novo ANLL; +22 may also occur apparently in the absence of inv(16), but cryptic rearrangements of MYH11 (16p13) and CBFB (16q22) have been found in a number of cases; for some authors, +22 indicates the obligate existence of an inv(16); for others +22 solely is a true entity
Cytogenetics Molecular	is appropriate to exclude or discover the presence of a hidden inv(16), inasmuch as inv(16) is associated with a relatively good prognosis
Additional anomalies	anomalies associated with +22 are del(7q) and/or +8, found in15% of cases each; this percentage is similar in cases with or without inv(16)