Atlas of Genetics and Cytogenetics in Oncology and Haematology

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+3 or trisomy 3 in non Hodgkin's lymphoma (NHL)

Clinics and Pathology

Disease trisomy 3 occurs more frequently in T-cell lymphomas than in B-cell lymphomas
  • globally, 20-30% of T-NHL may carry trisomy 3, the highest incidence having been noted in lymphoepithelioid lymphoma, in low-grade peripheral T-cell lymphoma, in angioimmonoblastic lymphadenopathy and in adult T-cell leukemia-lymphoma
  • trisomy 3 is relatively rare in B-NHL, with the exception of marginal zone lymphomas (MZL) and mantle cell lymphoma (MCL); in MZL, total or partial trisomy 3 may occur in 50-70% of cytogenetically abnormal cases, with a reported incidence by interphase FISH in the 50-85% range; the incidence does not appear to vary according to the clinicopathologic features, with similar frequency in the extra-nodal MALT lymphoma, in the nodal and the splenic form of MZL; trisomy 3/3q was reported in 10-15% of MCL with an higher incidence (up to 40%) by molecular cytogenetic techniques; sporadically, other low-grade and high grade B-lymphoid tumors may carry trisomy 3/3q
    • Prognosis the prognostic significance of trisomy 3 in T-cell and B-cell lymphomas is unknown; there does not appear to be a role for trisomy 3 in tumor progression from low-grade MALT lymphoma to the high grade form, whereas gains of 3q may be associated with the aggressive blastoid variant of MCL

    Cytogenetics

    Cytogenetics Morphological trisomy 3 may be total or partial; commonly overrepresented segments in partial trisomy 3 include the q21-23 region and the q25-29 region; total/partial trisomy 3 may occur as an isolated anomaly in a minority of cases
    Cytogenetics Molecular the anomaly is readily detectable by G- and R-banding in most cases; however, FISH using a centromeric probe is more sensitive than conventional cytogenetics, allowing for the study of non-dividing cells and for the detection of partial trisomy in complex karyotypes with marker chromosomes

    Genes involved and Proteins

    Note the gene(s) involved in the transformation process by gene dosage effect or by other mechanisms are not known

    External links

    Other database+3 or trisomy 3 in non Hodgkin's lymphoma (NHL) Mitelman database (CGAP - NCBI)

    Bibliography

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    Contributor(s)

    Written01-2001Antonio Cuneo, Gianluigi Castoldi

    Citation

    This paper should be referenced as such :
    Cuneo A and Castoldi GL . +3 or trisomy 3 in non Hodgkin's lymphoma (NHL). Atlas Genet Cytogenet Oncol Haematol. January 2001 .
    URL : http://AtlasGeneticsOncology.org/Anomalies/tri3NHLID2008.html

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    indexed on : Mon May 12 18:13:27 2008

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