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+3 or trisomy 3 in non Hodgkin's lymphoma (NHL)

Written2001-01Antonio Cuneo, Gianluigi Castoldi
Hematology Section, Department of Biomedical Sciences, University of Ferrara, Corso Giovecca 203, Ferrara, Italy

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Atlas_Id 2008
  +3 (right) and partial trisomy 3 due to i(3)(q10) (left) FISH - Courtesy Hossein Mossafa.

Clinics and Pathology

Disease trisomy 3 occurs more frequently in T-cell lymphomas than in B-cell lymphomas
  • globally, 20-30% of T-NHL may carry trisomy 3, the highest incidence having been noted in lymphoepithelioid lymphoma, in low-grade peripheral T-cell lymphoma, in angioimmonoblastic lymphadenopathy and in adult T-cell leukemia-lymphoma
  • trisomy 3 is relatively rare in B-NHL, with the exception of marginal zone lymphomas (MZL) and mantle cell lymphoma (MCL); in MZL, total or partial trisomy 3 may occur in 50-70% of cytogenetically abnormal cases, with a reported incidence by interphase FISH in the 50-85% range; the incidence does not appear to vary according to the clinicopathologic features, with similar frequency in the extra-nodal MALT lymphoma, in the nodal and the splenic form of MZL; trisomy 3/3q was reported in 10-15% of MCL with an higher incidence (up to 40%) by molecular cytogenetic techniques; sporadically, other low-grade and high grade B-lymphoid tumors may carry trisomy 3/3q
  • Prognosis the prognostic significance of trisomy 3 in T-cell and B-cell lymphomas is unknown; there does not appear to be a role for trisomy 3 in tumor progression from low-grade MALT lymphoma to the high grade form, whereas gains of 3q may be associated with the aggressive blastoid variant of MCL


    Cytogenetics Morphological trisomy 3 may be total or partial; commonly overrepresented segments in partial trisomy 3 include the q21-23 region and the q25-29 region; total/partial trisomy 3 may occur as an isolated anomaly in a minority of cases
    Cytogenetics Molecular the anomaly is readily detectable by G- and R-banding in most cases; however, FISH using a centromeric probe is more sensitive than conventional cytogenetics, allowing for the study of non-dividing cells and for the detection of partial trisomy in complex karyotypes with marker chromosomes

    Genes involved and Proteins

    Note the gene(s) involved in the transformation process by gene dosage effect or by other mechanisms are not known


    Correlation of chromosome abnormalities with histologic and immunologic characteristics in non-Hodgkin's lymphoma and adult T cell leukemia-lymphoma. Fifth International Workshop on Chromosomes in Leukemia-Lymphoma.
    Blood. 1987 ; 70 (5) : 1554-1564.
    PMID 2889485
    Increased number of chromosomal imbalances and high-level DNA amplifications in mantle cell lymphoma are associated with blastoid variants.
    Beá S, Ribas M, Hernández JM, Bosch F, Pinyol M, Hernández L, García JL, Flores T, González M, López-Guillermo A, Piris MA, Cardesa A, Montserrat E, Miró R, Campo E
    Blood. 1999 ; 93 (12) : 4365-4374.
    PMID 10361135
    Secondary chromosome changes in mantle cell lymphoma: cytogenetic and fluorescence in situ hybridization studies.
    Bigoni R, Cuneo A, Milani R, Roberti MG, Bardi A, Rigolin GM, Cavazzini F, Agostini P, Castoldi G
    Leukemia & lymphoma. 2001 ; 40 (5-6) : 581-590.
    PMID 11426530
    Marginal zone B-cell lymphomas of different sites share similar cytogenetic and morphologic features.
    Dierlamm J, Pittaluga S, Wlodarska I, Stul M, Thomas J, Boogaerts M, Michaux L, Driessen A, Mecucci C, Cassiman JJ, De Wolf-Peeters C, Van den Berghe H
    Blood. 1996 ; 87 (1) : 299-307.
    PMID 8547655
    Gastric low-grade MALT lymphoma, high-grade MALT lymphoma and diffuse large B cell lymphoma show different frequencies of trisomy.
    Hoeve MA, Gisbertz IA, Schouten HC, Schuuring E, Bot FJ, Hermans J, Hopman A, Kluin PM, Arends JW, van Krieken JH
    Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1999 ; 13 (5) : 799-807.
    PMID 10374886
    Trisomy 3q11-q29 is recurrently observed in B-cell non-Hodgkin's lymphomas associated with cold agglutinin syndrome.
    Michaux L, Dierlamm J, Wlodarska L, Criel A, Louwagie A, Ferrant A, Hagemeijer A, Van den Berghe H
    Annals of hematology. 1998 ; 76 (5) : 201-204.
    PMID 9671133
    Cytogenetic findings in peripheral T-cell lymphomas as a basis for distinguishing low-grade and high-grade lymphomas.
    Schlegelberger B, Himmler A, Gödde E, Grote W, Feller AC, Lennert K
    Blood. 1994 ; 83 (2) : 505-511.
    PMID 8286748


    This paper should be referenced as such :
    Cuneo, A ; Castoldi, GL
    +3 or trisomy 3 in non Hodgkin's lymphoma (NHL)
    Atlas Genet Cytogenet Oncol Haematol. 2001;5(1):44-45.
    Free journal version : [ pdf ]   [ DOI ]
    On line version :

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