Atlas of Genetics and Cytogenetics in Oncology and Haematology
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
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EPS15 (epidermal growth factor receptor pathway substrate 15)
| Identity |
| Other names | AF1p (ALL1 fused gene from chromosome 1p) |
| EPS15 (EGFR Pathway Substrate 15) | |
| MLLT5 (Myeloid/Lymphoid Leukemia Translocated to, 5) | |
| HGNC (Hugo) | EPS15 |
| LocusID (NCBI) | 2060 |
| Location | 1p32.3 |
| Location_base_pair | Starts at 51819935 and ends at 51887793 bp from pter ( according to hg19-Feb_2009) [Mapping] |
 | |
| AF1p (1p32) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics. | |
| DNA/RNA |
| Description | coding sequence: CDS 93..2783 |
| Transcription | 4.4 kb mRNA |
| Protein |
| Description | 896 amino acids; NH2 -- coiled-coil region -- DPF repeat -- COOH; oligomerization properties |
| Expression | wide |
| Localisation | cytoplasmic |
| Function | implicated in endocytocis; probable EGF receptor tyrosine kinase substrate. |
| Homology | PAN1 (yeast); eps15R (human) |
| Implicated in |
| Entity | t(1;11) (p32;q23)/ANLLL --> MLL - AF1p |
| Disease | AMMOL |
| Abnormal Protein | N-term -- AT hook and DNA methyltransferase from MLL fused to almost all AF1p |
| Other Leukemias implicated (Data extracted from papers in the Atlas) |
| Leukemias | 11q23ChildAMLID1615 | 11q23ID1030 | 11q23secondLeukID1131 |
| External links |
| Bibliography |
| eps15, a novel tyrosine kinase substrate, exhibits transforming activity. |
| Fazioli F, Minichiello L, Matoskova B, Wong WT, Di Fiore PP |
| Molecular and cellular biology. 1993 ; 13 (9) : 5814-5828. |
| PMID 7689153 |
| A novel gene, AF-1p, fused to HRX in t(1;11)(p32;q23), is not related to AF-4, AF-9 nor ENL. |
| Bernard OA, Mauchauffe M, Mecucci C, Van den Berghe H, Berger R |
| Oncogene. 1994 ; 9 (4) : 1039-1045. |
| PMID 8134107 |
| Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations. |
| Bernard OA, Berger R |
| Genes, chromosomes & cancer. 1995 ; 13 (2) : 75-85. |
| PMID 7542910 |
| 11q23 rearrangements in acute leukemia. |
| Rubnitz JE, Behm FG, Downing JR |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1996 ; 10 (1) : 74-82. |
| PMID 8558942 |
| Eps15 is a component of clathrin-coated pits and vesicles and is located at the rim of coated pits. |
| Tebar F, Sorkina T, Sorkin A, Ericsson M, Kirchhausen T |
| The Journal of biological chemistry. 1996 ; 271 (46) : 28727-28730. |
| PMID 8910509 |
| Chromosome abnormalities in leukaemia: the 11q23 paradigm. |
| Young BD, Saha V |
| Cancer surveys. 1996 ; 28 : 225-245. |
| PMID 8977038 |
| Pan1p, yeast eps15, functions as a multivalent adaptor that coordinates protein-protein interactions essential for endocytosis. |
| Wendland B, Emr SD |
| The Journal of cell biology. 1998 ; 141 (1) : 71-84. |
| PMID 9531549 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 04-1998 | Olivier Bernard |
| Citation |
| This paper should be referenced as such : |
| Bernard, O |
| EPS15 (epidermal growth factor receptor pathway substrate 15) |
| Atlas Genet Cytogenet Oncol Haematol. 1998;2(3):70-71. |
| Free journal version : [ pdf ] [ DOI ] |
| URL : http://AtlasGeneticsOncology.org/Genes/AF1pID11.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Tue Feb 17 20:27:26 CET 2015 |
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