EPS15 (epidermal growth factor receptor pathway substrate 15)
1998-04-01 Olivier Bernard AffiliationUnite Inserm U434, CNRS, Institut de Genetique Moleculaire, Paris, France
Identity
HGNC
LOCATION
1p32.3
IMAGE
LEGEND
AF1p (1p32) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.
LOCUSID
ALIAS
AF-1P,AF1P,MLLT5
FUSION GENES
DNA/RNA
Description
coding sequence: CDS 93..2783
Transcription
4.4 kb mRNA
Proteins
Description
896 amino acids; NH2 -- coiled-coil region -- DPF repeat --
COOH; oligomerization properties
Expression
wide
Localisation
cytoplasmic
Function
implicated in endocytocis; probable EGF receptor tyrosine kinase substrate.
Homology
PAN1 (yeast); eps15R (human)
Implicated in
Entity name
Disease
AMMOL
Fusion protein
N-term -- AT hook and DNA methyltransferase from MLL fused to
almost all AF1p
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 7542910 | 1995 | Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations. | Bernard OA et al |
| 7689153 | 1993 | eps15, a novel tyrosine kinase substrate, exhibits transforming activity. | Fazioli F et al |
| 8558942 | 1996 | 11q23 rearrangements in acute leukemia. | Rubnitz JE et al |
| 8910509 | 1996 | Eps15 is a component of clathrin-coated pits and vesicles and is located at the rim of coated pits. | Tebar F et al |
| 9531549 | 1998 | Pan1p, yeast eps15, functions as a multivalent adaptor that coordinates protein-protein interactions essential for endocytosis. | Wendland B et al |
| 8977038 | 1996 | Chromosome abnormalities in leukaemia: the 11q23 paradigm. | Young BD et al |
Other Information
Locus ID:
NCBI: 2060
MIM: 600051
HGNC: 3419
Ensembl: ENSG00000085832
Variants:
dbSNP: 2060
ClinVar: 2060
TCGA: ENSG00000085832
COSMIC: EPS15
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000085832 | ENST00000371730 | B1AUU8 |
| ENSG00000085832 | ENST00000371733 | P42566 |
| ENSG00000085832 | ENST00000465467 | S4R3U1 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37827695 | 2023 | Modified iPOND revealed the role of mutant p53 in promoting helicase function and telomere maintenance. | 0 |
| 37827695 | 2023 | Modified iPOND revealed the role of mutant p53 in promoting helicase function and telomere maintenance. | 0 |
| 33037466 | 2020 | EPS15-NTRK1: a novel NTRK1 oncogenic fusion in patient with lung adenocarcinoma. | 0 |
| 33037466 | 2020 | EPS15-NTRK1: a novel NTRK1 oncogenic fusion in patient with lung adenocarcinoma. | 0 |
| 28215104 | 2017 | Increased Eps15 homology domain 1 and RAB11FIP3 expression regulate breast cancer progression via promoting epithelial growth factor receptor recycling. | 13 |
| 28228550 | 2017 | Interaction of phosphorylated Rab11-FIP2 with Eps15 regulates apical junction composition. | 3 |
| 28215104 | 2017 | Increased Eps15 homology domain 1 and RAB11FIP3 expression regulate breast cancer progression via promoting epithelial growth factor receptor recycling. | 13 |
| 28228550 | 2017 | Interaction of phosphorylated Rab11-FIP2 with Eps15 regulates apical junction composition. | 3 |
| 26748853 | 2016 | USP9X Controls EGFR Fate by Deubiquitinating the Endocytic Adaptor Eps15. | 45 |
| 27008177 | 2016 | A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes. | 32 |
| 27237791 | 2016 | Transient Fcho1/2⋅Eps15/R⋅AP-2 Nanoclusters Prime the AP-2 Clathrin Adaptor for Cargo Binding. | 52 |
| 26748853 | 2016 | USP9X Controls EGFR Fate by Deubiquitinating the Endocytic Adaptor Eps15. | 45 |
| 27008177 | 2016 | A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes. | 32 |
| 27237791 | 2016 | Transient Fcho1/2⋅Eps15/R⋅AP-2 Nanoclusters Prime the AP-2 Clathrin Adaptor for Cargo Binding. | 52 |
| 26289382 | 2015 | Over-expression of EPS15 is a favorable prognostic factor in breast cancer. | 4 |
Citation
Olivier Bernard
EPS15 (epidermal growth factor receptor pathway substrate 15)
Atlas Genet Cytogenet Oncol Haematol. 1998-04-01
Online version: http://atlasgeneticsoncology.org/gene/11/eps15-(epidermal-growth-factor-receptor-pathway-substrate-15)
