| Written | 1998-04 | Olivier Bernard |
| Unite Inserm U434, CNRS, Institut de Genetique Moleculaire, Paris, France |
| Identity |
| Alias_names | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog |
| Alias_symbol (synonym) | AF1Q |
| Other alias | AF1q (ALL1 fused gene from chromosome 1q) |
| HGNC (Hugo) | MLLT11 |
| LocusID (NCBI) | 10962 |
| Atlas_Id | 12 |
| Location | 1q21.3 [Link to chromosome band 1q21] |
| Location_base_pair | Starts at 151059675 and ends at 151068497 bp from pter ( according to hg19-Feb_2009) [Mapping MLLT11.png] |
 | |
| AF1q (1q21) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics. | |
| Fusion genes (updated 2017) | Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands) |
| GABPB2 (1q21.3) / MLLT11 (1q21.3) | KMT2A (11q23.3) / MLLT11 (1q21.3) | MLLT11 (1q21.3) / ENC1 (5q13.3) | |
| MLLT11 (1q21.3) / KMT2A (11q23.3) | PIP5K1A (1q21.3) / MLLT11 (1q21.3) | SHMT1 (17p11.2) / MLLT11 (1q21.3) | |
| DNA/RNA |
| Transcription | 1.8 kb mRNA; coding sequence CDS 401... 673 |
| Protein |
| Description | 90 amino acids; 9 kDa |
| Expression | detected in various tissues (small intestine, colon, thymus mainly), but not in (normal) mature blood cells; expressed in all leukemic cell lines tested |
| Function | unknown |
| Homology | no known homology |
| Implicated in |
| Note | |
| Entity | t(1;11) (q21;q23)/AML --> KMT2A - MLLT11 |
| Disease | AML |
| Prognosis | yet unknown |
| Hybrid/Mutated Gene | breakpoints: between exons 6 and 7 in MLL and within the 5' untranslated region in AF1q |
| Abnormal Protein | N-term -- AT hook and DNA methyltransferase from MLL fused to the entire AF1q on the der(11); the reciprocal on der(1) is out of frame |
| Bibliography |
| Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations. |
| Bernard OA, Berger R |
| Genes, chromosomes & cancer. 1995 ; 13 (2) : 75-85. |
| PMID 7542910 |
| 11q23 rearrangements in acute leukemia. |
| Rubnitz JE, Behm FG, Downing JR |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1996 ; 10 (1) : 74-82. |
| PMID 8558942 |
| A novel gene, AF1q, fused to MLL in t(1;11) (q21;q23), is specifically expressed in leukemic and immature hematopoietic cells. |
| Tse W, Zhu W, Chen HS, Cohen A |
| Blood. 1995 ; 85 (3) : 650-656. |
| PMID 7833468 |
| Chromosome abnormalities in leukaemia: the 11q23 paradigm. |
| Young BD, Saha V |
| Cancer surveys. 1996 ; 28 : 225-245. |
| PMID 8977038 |
| Citation |
| This paper should be referenced as such : |
| Bernard, O |
| AF1q (ALL1 fused gene from chromosome 1q) |
| Atlas Genet Cytogenet Oncol Haematol. 1998;2(3):72-72. |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://AtlasGeneticsOncology.org/Genes/AF1qID12.html |
| Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ] |
|
11q23 rearrangements (KMT2A) in therapy related leukaemias
t(1;11)(q21;q23) KMT2A/MLLT11 |
| Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ] |
|
GABPB2/MLLT11 (1q21)
PIP5K1A/MLLT11 (1q21) |
| External links |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Dec 10 13:37:00 CET 2018 |
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