MLLT11 (ALL1 fused gene from chromosome 1q)

1998-04-01   Olivier Bernard  

Unite Inserm U434, CNRS, Institut de Genetique Moleculaire, Paris, France

Identity

HGNC
MLLT11
LOCATION
1q21.3
IMAGE
Atlas Image
LEGEND
AF1q (1q21) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.
LOCUSID
10962
ALIAS
AF1Q
FUSION GENES
Show Gene Fusions

DNA/RNA

Transcription

1.8 kb mRNA; coding sequence CDS 401... 673

Proteins

Description

90 amino acids; 9 kDa

Expression

detected in various tissues (small intestine, colon, thymus mainly), but not in (normal) mature blood cells; expressed in all leukemic cell lines tested

Function

unknown

Homology

no known homology

Implicated in

Entity name
t(1;11) (q21;q23)/AML --> KMT2A - MLLT11
Disease
AML
Prognosis
yet unknown
Hybrid gene
breakpoints: between exons 6 and 7 in MLL and within the 5 untranslated region in AF1q
Fusion protein
N-term -- AT hook and DNA methyltransferase from MLL fused to the entire AF1q on the der(11); the reciprocal on der(1) is out of frame

Article Bibliography

Pubmed IDLast YearTitleAuthors
75429101995Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations.Bernard OA et al
8558942199611q23 rearrangements in acute leukemia.Rubnitz JE et al
78334681995A novel gene, AF1q, fused to MLL in t(1;11) (q21;q23), is specifically expressed in leukemic and immature hematopoietic cells.Tse W et al
89770381996Chromosome abnormalities in leukaemia: the 11q23 paradigm.Young BD et al

Other Information

Locus ID:

NCBI: 10962
MIM: 604684
HGNC: 16997
Ensembl: ENSG00000213190

Variants:

dbSNP: 10962
ClinVar: 10962
TCGA: ENSG00000213190
COSMIC: MLLT11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000213190ENST00000368921Q13015
ENSG00000213190ENST00000368921Q6FGF7

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380755522023MLLT11 siRNA Inhibits the Migration and Promotes the Apoptosis of MDA-MB-231 Breast Cancer Cells.0
382036102023MLLT11 Regulates Endometrial Stroma Cell Adhesion, Proliferation and Survival in Ectopic Lesions of Women with Advanced Endometriosis.0
380755522023MLLT11 siRNA Inhibits the Migration and Promotes the Apoptosis of MDA-MB-231 Breast Cancer Cells.0
382036102023MLLT11 Regulates Endometrial Stroma Cell Adhesion, Proliferation and Survival in Ectopic Lesions of Women with Advanced Endometriosis.0
348283712021A Monoallelic Variant in REST Is Associated with Non-Syndromic Autosomal Dominant Hearing Impairment in a South African Family.4
348283712021A Monoallelic Variant in REST Is Associated with Non-Syndromic Autosomal Dominant Hearing Impairment in a South African Family.4
312735462020AF1q Expression Associates with CD44 and STAT3 and Impairs Overall Survival in Adenoid Cystic Carcinoma of the Head and Neck.3
329649802020LPAR5 stimulates the malignant progression of non-small-cell lung carcinoma by upregulating MLLT11.7
312735462020AF1q Expression Associates with CD44 and STAT3 and Impairs Overall Survival in Adenoid Cystic Carcinoma of the Head and Neck.3
329649802020LPAR5 stimulates the malignant progression of non-small-cell lung carcinoma by upregulating MLLT11.7
316716952019The Oncogene AF1Q is Associated with WNT and STAT Signaling and Offers a Novel Independent Prognostic Marker in Patients with Resectable Esophageal Cancer.7
316716952019The Oncogene AF1Q is Associated with WNT and STAT Signaling and Offers a Novel Independent Prognostic Marker in Patients with Resectable Esophageal Cancer.7
301544352018Novel AF1q/MLLT11 favorably affects imatinib resistance and cell survival in chronic myeloid leukemia.5
301544352018Novel AF1q/MLLT11 favorably affects imatinib resistance and cell survival in chronic myeloid leukemia.5
275105062017The Interaction of TXNIP and AFq1 Genes Increases the Susceptibility of Schizophrenia.5

Citation

Olivier Bernard

MLLT11 (ALL1 fused gene from chromosome 1q)

Atlas Genet Cytogenet Oncol Haematol. 1998-04-01

Online version: http://atlasgeneticsoncology.org/gene/12/mllt11-(all1-fused-gene-from-chromosome-1q)