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NCKIPSD (NCK interacting protein with SH3 domain)

Written2000-02Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

Other alias
LocusID (NCBI) 51517
Atlas_Id 228
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at and ends at bp from pter
 
  Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CELSR3 (3p21.31) / NCKIPSD (3p21.31)KMT2A (11q23.3) / NCKIPSD (3p21.31)NCKIPSD (3p21.31) / CELSR3 (3p21.31)
NCKIPSD (3p21.31) / KMT2A (11q23.3)NCKIPSD (3p21.31) / LPP (3q28)SEC14L6 (22q12.2) / NCKIPSD (3p21.31)

DNA/RNA

Description 2990 bp cDNA

Protein

Description 722 amino acids; N-term SH3 domain, proline-rich domain, and a nuclear localization signal in C-term
Expression wide

Implicated in

Note
  
Entity t(3;11)(p21;q23) --> NCKIPSD -KMT2A
Disease treatment related acute non lymphoblastic leukemia (t-AML)
Hybrid/Mutated Gene 5 prime MLL-3 prime AF3q21
Abnormal Protein AT hooks and methyltransferase domains of MLL in the N-term fused to the proline-rich domain and nuclear localization signal of AF3p21
  

Bibliography

Isochromosome 17q in blast crisis of chronic myeloid leukemia and in other hematologic malignancies is the result of clustered breakpoints in 17p11 and is not associated with coding TP53 mutations.
Fioretos T, Strömbeck B, Sandberg T, Johansson B, Billström R, Borg A, Nilsson PG, Van Den Berghe H, Hagemeijer A, Mitelman F, Höglund M
Blood. 1999 ; 94 (1) : 225-232.
PMID 10381517
 

Citation

This paper should be referenced as such :
Huret, JL
AF3p21 (ALL1 fused gene from chromosome 3p21)
Atlas Genet Cytogenet Oncol Haematol. 2000;4(1):13-13.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/AF3p21ID228.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 6 ]
  t(3;11)(p21;q23) KMT2A/NCKIPSD
t(3;3)(p21;p21) NCKIPSD/CELSR3
11q23 rearrangements (KMT2A) in leukaemia
t(3;4)(p21;q34)
t(3;11)(p21;q23) KMT2A/NCKIPSD
t(3;3)(p21;p21) NCKIPSD/CELSR3


External links

Nomenclature
Cards
AtlasAF3p21ID228.txt
Aliases
Genomic and cartography
Gene and transcription
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)51517
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Protein Interaction databases
Ontologies - Pathways
Clinical trials, drugs, therapy
Miscellaneous
canSAR (ICR) (select the gene name)
Probes
Litterature
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed


© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Oct 18 17:27:32 CEST 2018

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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.